Research Associate I/II, Protein Sciences

The role

This role supports recombinant protein production at Fathem. You will focus on the expression, purification, and characterization of protein targets including membrane proteins and cryo-EM–ready samples.

What you will do

• Support recombinant protein production
• Express, purify, and characterize challenging protein targets
• Build robust purification workflows and characterization assays
• Feed data into next-generation computational models
• Document work in an ELN
• Maintain lab organization and inventories

Required qualifications

• Bachelor’s degree in Biochemistry or a related field, with a minimum of 2 years relevant experience in an academic or industry laboratory or a MS degree in Biochemistry or a related field
• Hands-on experience in recombinant protein expression and purification, encompassing transformation/transfection and chromatographic techniques (affinity, ion-exchange, and size-exclusion)
• Familiarity with protein construct design and analytical techniques including size-exclusion chromatography, dynamic light scattering, and thermostability assays
• Proven ability to rigorously document work in an ELN and maintain lab organization and inventories

Nice to have

• More than one year of experience with recombinant protein production and purification in an industry setting
• Proficiency with ÄKTA systems and UNICORN software
• Experience implementing protein characterization and binding assays, e.g. ELISA, BLI, and/or enzymatic activity
• Proficiency across multiple protein expression systems, such as bacterial, mammalian, insect, yeast, and/or cell-free platforms
• Experience generating proteins for high-resolution cryo-electron microscopy (cryo-EM) applications
• Demonstrated expertise in the purification and characterization of membrane proteins
• Experience with automation in a biochemistry context
• Experience with antibody or antibody fragment production and purification

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other benefits

About the company

Flagship Labs 109, Inc. (FL109) is a privately held, early-stage technology company pioneering the use of artificial intelligence, physics and hardware to transform the way we see biology. FL109 was conceived by Flagship Pioneering.