Senior Scientist, Discovery Science

The role

The Senior Scientist will lead assay development and tissue processing in the Discovery Biology team at FL125, a biotechnology platform company developing oligonucleotide therapies. The role works closely with in vivo biologists, NGS scientists, bioinformatics teams and contract research organizations (CROs).

What you will do

• Drive translational platform innovation with a focus on biochemical assay development, analysis of oligonucleotides in complex mixtures, and tissue processing.
• Generate and develop enhanced oligonucleotides in different biological settings and against a broad set of drug targets.
• Support the design of in vivo experiments based on protocols developed in vitro.
• Work in close collaboration with biochemists, in vivo biologists, NGS scientists and bioinformatics teams.
• Work closely with CROs conducting in vitro and in vivo experiments to identify new drug molecules.
• Generate rapid, accurate turnaround of high-quality experimental data to drive decisions for platform and pipeline programs.
• Establish and refine workflows, SOPs and documentation practices for experimental processes at scale.
• Communicate experimental design, results, challenges and next steps in internal meetings and with external collaborators.

Required qualifications

• PhD in molecular biology, biochemistry, drug discovery or a related field, with 3+ years of industry experience in discovery research. Postdoctoral experience may also be acceptable depending on resea
• Hands-on experience designing and interpreting complex in vitro and ex vivo experimental workflows, including sample processing and assay development.
• Good understanding of in vivo experiments for drug discovery and development in mouse models.
• Some familiarity with high-dimensional readouts such as NGS and proteomics.
• Hands-on experience with standard biochemical techniques and an ability to troubleshoot and optimize complex experimental workflows.
• Track record of working in multidisciplinary teams, including biochemists, in vivo biologists and bioinformaticians.
• Motivated team player and independent worker with strong organizational and written and verbal communication skills.

Nice to have

• Experience working with oligonucleotides.
• Experience designing and executing mouse model experiments.
• Experience working with contract research organizations (CROs).

Benefits

• Opportunity to lay the scientific foundation of a transformative platform company as an early employee.
• A custom-tailored role to maximize impactful contributions, professional growth and scientific interests.
• Tightly knit team, social activities and community lunchroom with free snacks.
• Healthcare coverage.
• Annual incentive program.
• Retirement benefits.
• A broad range of other benefits.

Before you apply

• Flagship Pioneering does not accept unsolicited resumes from recruitment or staffing agencies unless contacted directly by its Talent Acquisition team.

About the company

FL125 is a biotechnology platform company developing oligonucleotide therapies for therapeutic, diagnostic and tool development. It is backed by Flagship Pioneering, a bioplatform innovation company that has founded more than 100 scientific ventures.