Senior Development Scientist I

The role

You will develop, optimize, verify, and validate clinical-grade assay technologies for a multiomic platform. You will work across manual and automated workflows to transfer NGS-based assays into a regulated, high-throughput production environment.

What you will do

• Apply knowledge of molecular biology, nucleic-acid biochemistry, and next-generation sequencing to develop assays for DNA.
• Oversee and lead experiments to optimize, characterize, verify, and validate NGS-based assays.
• Design and execute experiments, generate documentation, perform data analysis, and present results.
• Troubleshoot complex technical challenges and drive process improvements.
• Drive project planning and prioritization by defining milestones and mitigating risks.
• Partner cross-functionally to transition development protocols into clinical production.
• Document product development requirements and author study protocols and reports.
• Apply current Good Laboratory and Documentation Practices (cGLP, cGDP).

Required qualifications

• PhD in molecular biology, biochemistry, genetics, or a related field with at least 4 years of professional experience in the life sciences, or a Bachelors or Masters degree with at least 10 years of p
• Experience designing and leading the execution of verification and validation studies for IVD assays in a regulated clinical laboratory environment (GLP).
• Extensive hands-on experience in Next-gen sequencing (NGS) based automated assay development including extraction, library preparation, target capture, and sequencing.
• Experience working with automated platforms and liquid handlers.
• Extensive hands-on experience in nucleic acid preparation, amplification, and quantification (DNA/RNA extraction and purification, PCR, qPCR, Qubit, Fragment Analyzer, Tapestation).
• Experience in working with ctDNA/cfDNA as an analyte in NGS workflows.
• Proven track record of designing, planning, and executing successful experiments, including performing independent data analysis and giving effective scientific presentations.
• High attention to detail and ability to record accurate and detailed observations, assess impact, and lead independent troubleshooting investigations.
• Excellent written and verbal communication.
• Proactive communicator with ability to foster collaboration in a multidisciplinary team.
• Flexible and highly motivated to learn new skills and comfortable adapting to changing priorities.
• Experience providing technical mentorship and training to other scientists and research associates.

Nice to have

• Prior experience in clinical diagnostics and/or working in a start-up environment
• Experience in working with methylated ctDNA/cfDNA as an analyte in NGS workflows
• Familiarity with scientific programming or data analysis tools such as Python or R
• Experience contributing to publications, patents, or other scientific innovations

Benefits

• Equity
• Cash bonuses
• Medical benefits
• Financial benefits
• Other benefits

About the company

Freenome is an organization dedicated to changing the landscape of cancer by detecting it earlier using a multiomic platform.