Senior Director, Protein Analytics & Biophysics

The role

This leader will set the vision for measuring biophysical, biochemical, and interaction properties of protein therapeutics. You will lead the Protein Analytics & Biophysics function to develop next-generation measurement platforms and scale experimental systems.

What you will do

• Set and drive the multi-year scientific and organizational vision for Protein Analytics & Biophysics.
• Define next generation biophysical, biochemical, developability, and protein-protein interaction measurement capabilities.
• Lead the evolution of conventional analytical and interaction workflows.
• Build a strategy connecting conventional technologies with emerging pooled or massively multiplexed approaches.
• Partner with multiple internal teams to design, operationalize, validate, and scale new assay concepts.
• Identify and implement technologies to improve throughput, sensitivity, and sample consumption.
• Establish data standards, quality expectations, and analytical frameworks.
• Ensure the function generates high-quality data across Discovery, Candidate Selection, and early Development.
• Drive operational excellence including resource planning, milestone delivery, and metrics.
• Lead, coach, and develop a high-performing team of managers and scientists.

Required qualifications

• Ph.D. in Biophysics, Biochemistry, Molecular Biology, Chemical Biology, Bioengineering, Synthetic Biology, Protein Engineering, or a related scientific discipline; or equivalent depth of industry expe
• 12+ years experience in biopharma, biotechnology, synthetic biology, protein engineering, or a related field.
• Substantial leadership experience in protein analytics, biophysics, developability, and protein-protein interaction characterization.
• Track record of building, inventing, or scaling novel assay platforms for protein therapeutics.
• Ability to create experimental systems that generate high-dimensional, quantitative data for AI/ML-enabled protein design.
• Deep technical expertise in HPLC/UPLC, LC/MS, CE-SDS, cIEF, DSF, DSC, DLS, SEC-MALS, SPR, BLI, and related technologies.
• Strong understanding of protein-protein interaction measurement including affinity, kinetics, specificity, cross-reactivity, epitope/binning, avidity, and context-dependent binding behavior.
• Strong quantitative mindset and experience using data quality, assay statistics, modeling, and informatics.
• Experience partnering with prototyping, automation, engineering, computational, and technology teams.
• Demonstrated success as a senior people leader, including leading leaders and scaling teams.
• Exceptional collaboration and communication skills.
• Experience advancing biologics programs across Discovery and early Development.

Nice to have

• Experience creating platform capabilities that support machine learning-enabled discovery, closed-loop experimental systems, or large-scale design-build-test-learn cycles.
• Experience with pooled screening strategies, DNA-encoded or barcode-linked readouts, sequencing-based measurements, display technologies, high-throughput synthetic biology, or massively multiplexed pr
• Experience developing assays that require very low material input, operate at micro- or nanoscale, or integrate microfluidics, acoustic dispensing, advanced imaging, high-content detection, or next-ge
• Experience serving as an external scientific spokesperson, thought leader, founder-like platform builder, or conference presenter.
• Familiarity with regulatory expectations and analytical strategy in support of candidate selection and early development.

Benefits

• Annual bonus
• Equity compensation
• Competitive benefits package

About the company

Generate:Biomedicines is a clinical-stage generative biology company pioneering the AI revolution in drug design and development. The company integrates machine learning with large-scale experimentation to design proteins with defined biological intent.