Senior Scientist I, Biotherapeutic Production Technologies

The role

This individual-contributor role leads complex protein production and characterization efforts. You will work across upstream expression, downstream purification, and analytical characterization to support drug discovery and platform initiatives.

What you will do

• Define, plan, and execute protein production, purification, and characterization strategies.
• Lead design, optimization, scale-up, and troubleshooting of protein expression workflows.
• Lead purification workflow development from capture through polishing.
• Produce high-quality protein material across various formats and scales.
• Select and interpret analytical and biochemical characterization methods.
• Integrate expression, purification, and characterization data to resolve technical challenges.
• Serve as a technical point of contact for protein production and characterization strategy.
• Lead technical interactions with CROs, CDMOs, and vendors.
• Drive development of scalable, reproducible, and well-documented workflows.
• Develop new methods, technical standards, and best practices while mentoring colleagues.

Required qualifications

• Ph.D. in biochemistry, molecular biology, bioengineering, chemical engineering, protein sciences, or a related discipline, with typically 4 or more years of relevant industry experience; or
• B.S. or M.S. in a relevant scientific or engineering discipline, with typically 12 or more years of relevant industry experience; or
• An equivalent combination of education and experience that demonstrates the technical depth, independent judgment, and scope of impact required for the role.

Nice to have

• Experience with stable-expression systems and stable cell-line development activities.
• Experience with construct design, cloning, vector design, or related molecular-biology workflows.
• Experience working with engineered proteins, multispecifics, novel scaffolds, or other complex protein modalities.
• Experience integrating protein design information into expression, purification, or characterization strategies.
• Experience with automation, high-throughput experimentation, laboratory information systems, or structured experimental-data environments.
• Experience managing technical work conducted by CRO, CDMO, or vendor partners.
• Experience developing workflows or methods that were adopted beyond an immediate project or work group.

Benefits

• Annual bonus
• Equity compensation
• Competitive benefits package

About the company

Generate:Biomedicines is a clinical-stage generative biology company pioneering the AI revolution in drug design and development. The company integrates machine learning with large-scale experimentation to design proteins with defined biological intent.