Associate Director, Biotherapeutic Production and Characterization

The role

You will lead a scientific team in protein production, purification and characterization for discovery and early development. You will be accountable for delivering assay-ready protein reagents and data that support program decisions.

What you will do

• Oversee protein production across mammalian, bacterial and cell-free systems, from construct design to assay-ready handoff
• Drive innovation for difficult antigens and complex proteins through construct optimization, tag selection, alternate expression systems and automation
• Establish production, purification and characterization standards for yield, purity, aggregation, concentration, identity, stability and biotinylation
• Lead portfolio planning, prioritization and resource allocation across internal and outsourced activities
• Manage relationships with CROs, technology providers and other external partners
• Represent the team on cross-functional program and platform teams
• Lead adoption of automation, structured data practices, AI/ML tools and agentic workflows
• Lead, coach and develop a high-performing team spanning construct design, expression, purification, characterization and reagent operations
• Provide timely feedback and create equitable opportunities for technical and leadership growth
• Build a culture of technical excellence, inclusion, integrity, urgency and collaboration

Required qualifications

• PhD in biochemistry, molecular biology, chemical engineering, bioengineering, protein sciences or a related discipline, with 8 years of relevant industry experience; or an M.S. in a related discipline
• Demonstrated success leading and developing scientific teams in a biotechnology or pharmaceutical environment
• Experience producing or characterizing complex biologics, including multispecific antibodies
• Expert technical knowledge across protein expression, purification and characterization
• Strong experience with construct design and optimization, protein formats, boundary engineering, affinity tags or site-specific labeling
• Strong experience with mammalian expression systems
• Strong expertise in protein purification methods, including affinity capture and size-exclusion chromatography
• Strong understanding of analytical and biochemical characterization methods for purity, aggregation, concentration, identity, stability and oligomeric state
• Experience establishing and managing relationships with CROs, vendors or external technology partners
• A track record of improving workflows, implementing new technologies and increasing throughput, reproducibility or efficiency
• Strong resource-planning and prioritization skills
• Ability to apply advanced judgment to complex scientific and operational problems

Nice to have

• Experience with cell-free or other specialized expression systems

Benefits

• Annual bonus
• Equity compensation
• Competitive benefits package

Before you apply

• Final base salary depends on skills, experience, internal equity, education or training and market dynamics

About the company

Generate:Biomedicines is a clinical-stage generative biology company founded in 2018 that designs proteins with defined biological intent using machine learning and large-scale experimentation. It advances a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities.