Senior Scientist I, Protein Analytics & Biophysics

The role

The Senior Scientist I will lead and contribute to analytical characterization, separation science, and biophysical workflows. This role assesses protein quality, stability, developability, and molecular interactions to support discovery programs and a machine learning-powered platform.

What you will do

• Lead and execute hands-on analytical and biophysical workflows to assess protein stability, aggregation, self-association, and polyreactivity.
• Develop, optimize, and troubleshoot separation workflows for protein characterization.
• Perform and expand binding analyses using SPR or related technologies.
• Contribute to mass spectrometry workflows to characterize protein identity and modifications.
• Design experiments, establish controls, interpret data, and recommend follow-up studies.
• Work with project teams to define analytical plans and communicate results.
• Serve as a technical and strategic representative for Protein Analytics & Biophysics on projects.
• Provide technical leadership in method development and workflow improvements.
• Operate, maintain, and troubleshoot laboratory instrumentation and automated platforms.
• Support training, knowledge sharing, and documentation.

Required qualifications

• Ph.D. in biochemistry, biophysics, analytical chemistry, protein science, or a related discipline with 4+ years of relevant research experience; or M.S. with 8+ years of relevant experience; equivalen
• Strong hands-on expertise in biophysical characterization of proteins.
• Practical experience with protein separation science and chromatography, such as SEC, IEX, HIC, capillary electrophoresis, or related methods.
• Ability to independently plan experiments, troubleshoot complex workflows, interpret data, and recommend next steps.
• Demonstrated method-development experience.
• Ability to represent a technical and strategic function on cross-functional project teams.
• Experience providing technical guidance, mentoring colleagues, or leading method and workflow improvements.
• Willingness to learn new assays and instrumentation and remain actively engaged in laboratory work.
• Strong documentation, organization, written communication, and collaboration skills.

Nice to have

• Experience with SPR or related binding technologies
• Experience with BLI or other kinetic and affinity-based assays
• Experience with general mass spectrometry, proteomics, structural mass spectrometry, or molecular barcoding
• Interest in working at the interface of experimental protein analytics, data science, and machine-learning-enabled discovery

Benefits

• Annual bonus
• Equity compensation
• Competitive benefits package

Before you apply

• Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates.

About the company

Generate Biomedicines is a clinical-stage generative biology company pioneering the AI revolution in drug design and development. The company integrates machine learning with large-scale experimentation to design proteins with defined biological intent.