Scientist II, Functional Bioassays & High Throughput Screening

The role

The Scientist II will develop, optimize, and execute functional assays to guide protein design and program decisions. This bench-focused role involves high-throughput screening and supporting automation integration across therapeutic programs.

What you will do

• Design, optimize, and implement high-throughput screening-compatible cell-based and biochemical assays.
• Plan and execute plate-based high-throughput screening campaigns.
• Analyze and interpret experimental datasets.
• Communicate findings to program teams to inform AI/ML-enabled design cycles.
• Support high-throughput functional assay work across multiple therapeutic programs.
• Troubleshoot assay performance, instrumentation, reagents, and workflows.
• Maintain accurate, timely, and well-organized records in electronic laboratory notebooks.
• Prepare clear summaries of results for team discussions and program updates.
• Coordinate experiments with cross-functional teams.
• Follow laboratory safety practices and scientific standards.

Required qualifications

• PhD in cell biology, pharmacology, immunology, biochemistry, bioengineering, molecular biology, or a related discipline, with approximately 2+ years of industry or postdoctoral experience; or MS with
• Hands-on experience with cell-based, biochemical, and functional assays in an academic, biotech, pharmaceutical, or related research setting.
• Strong technical foundation in mammalian cell culture and plate-based assay workflows.
• Experience with plate-based assay technologies such as ELISA, HTRF, AlphaLISA, luminescence or fluorescence assays, flow cytometry, or similar methods.
• Experience designing, optimizing, and executing high-throughput screening in 384- or 1536-well formats for small molecules, biologics, or both.
• Ability to recognize assay-performance or data-quality issues and contribute to troubleshooting.
• Ability to work effectively in a fast-paced, matrixed research environment.
• Strong organizational skills and the ability to manage multiple experiments or workstreams.
• Ability to analyze and present data at scale using tools such as Spotfire, Dotmatics, ScreenWorks, Harmony, iQue Forecyt, or similar platforms.
• Strong written and verbal communication skills.

Nice to have

• Experience with ion-channel assays or related functional readouts, such as patch clamp, membrane-potential, thallium-flux assays, or electrophysiology workflows.
• Experience with GPCR assays, including reporter, calcium-flux, cAMP, IP-one, beta-arrestin, or other pathway-based functional assays.
• Experience with ADC, image-based internalization, targeted protein degradation, immune-cell, or cytotoxicity assay formats.
• Experience with organoid-based screening workflows.
• Experience working with primary cells, engineered cell lines, or stable cell-line generation.
• Experience with laboratory automation systems such as HighRes, Beckman Biomek i5/i7, Hamilton, EL406, Multidrop, or equivalent liquid-handling platforms.
• Interest in applying functional biology to AI/ML-enabled therapeutic discovery.

Benefits

• Annual bonus
• Equity compensation
• Competitive benefits package

About the company

Generate:Biomedicines is a clinical-stage generative biology company pioneering the AI revolution in drug design and development. The company integrates machine learning with large-scale experimentation to design proteins with defined biological intent.