Scientist/Sr. Scientist, Chemical Biology

The role

You will work with the Chemistry and Platform Teams to develop core drug discovery technology and novel therapeutics. This role involves designing bifunctional molecules and supervising synthetic efforts with CROs.

What you will do

• Supervising synthetic efforts with CROs
• Designing, performing, and analyzing in cellulo assays
• Designing and optimizing first-in-class bifunctional molecules
• Collaborating with the Drug Discovery and IP team on patent applications
• Providing input for mechanistic studies on lead drug molecules
• Spearheading forays into new disease areas

Required qualifications

• PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field
• Chemical Biology with Medicinal Chemistry experience
• Deep understanding of small-molecule drug discovery and its relationship to human disease
• Able to work fluently at the interface of chemistry and biology
• Top-notch written and oral communication skills
• Experience designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
• Contributing to hit-to-lead and lead optimization studies
• Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK
• Experience with mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation)
• Experience with PPI assays (e.g., BRET, APEX/BioID, AlphaScreen)

Nice to have

• Industry experience
• Proficiency in HTS and phenotypic assay development
• Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
• Computational or molecular dynamics drug discovery experience
• DEL experience
• Experience managing others, especially synthetic chemistry CRO teams
• Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage
• One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Meditation retreats
• Reading budget

About the company

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). The company uses an OmniTAC drug discovery engine to furnish molecules that co-opt existing cellular machinery.