Sr. Scientist/Principal Scientist, Medicinal Chemistry

The role

You will design and advance medicinal chemistry strategies for next-generation induced proximity medicines. You will lead compound design, manage external CROs, and partner with cross-functional teams to drive programs from concept through lead optimization.

What you will do

• Design and advance medicinal chemistry strategies for next-generation induced proximity medicines.
• Lead compound design and SAR campaigns from hit finding through lead optimization.
• Manage external chemistry CROs including design prioritization, execution, and data review.
• Direct external DMPK studies and interpret in vitro and in vivo data.
• Partner with Biology and Platform teams to design screening strategies.
• Contribute to mechanistic studies to inform program direction.
• Support intellectual property strategy through invention generation and patent filings.
• Help evaluate and expand opportunities into new disease areas.

Required qualifications

• PhD in Chemistry, Medicinal Chemistry, or a related field.
• Minimum of 5 years of industry experience in small-molecule drug discovery.
• Strong foundation in medicinal chemistry and its application to disease-focused drug discovery.
• Experience designing, synthesizing, and optimizing induced proximity medicines, including PROTACs or related approaches.
• Experience across hit finding, hit-to-lead, and lead optimization.
• Experience building follow-up strategy for HTS, DNA-encoded or phenotypic screening follow-up.
• Demonstrated success optimizing compounds for oral exposure and interpreting pharmacokinetic data across multiple species.
• Deep understanding of physicochemical properties and in vitro DMPK parameters.
• Experience managing external chemistry CROs and driving synthetic programs efficiently.
• Excellent written and verbal communication skills.

Nice to have

• Experience contributing to programs that advanced from discovery into clinical development
• Background in computational chemistry, molecular modeling, or molecular dynamics
• Familiarity with chemical biology or structural biology techniques
• Experience with HTS or phenotypic screening
• Experience in proteomics, including PTM analysis or chemoproteomic target deconvolution

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage
• One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Meditation retreats
• Reading budget

About the company

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs) using an OmniTAC drug discovery engine. The company values a writing-first culture and an independent, can-do attitude.