Scientist, Medicinal Chemistry

The role

You will work with the Chemistry and Platform Teams to develop core drug discovery technology and a novel class of therapeutics. This involves designing bifunctional molecules and performing in cellulo assays.

What you will do

• Designing and optimizing first-in-class bifunctional molecules
• Assessing SAR to inform iterative medicinal chemistry optimization
• Supervising synthetic efforts with CRO partners
• Performing and analyzing in cellulo assays
• Collaborating with Drug Discovery and IP teams on patent applications
• Contributing mechanistic insight on lead drug molecules

Required qualifications

• PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field
• Deep understanding of small-molecule drug discovery and its relationship to human disease
• Able to work fluently at the interface of chemistry and biology
• Top-notch written and oral communication skills
• Experience in design, synthesis, and optimization of induced proximity medicines (e.g. PROTACs or other IPMs)
• Experience in hit-to-lead and lead optimization campaigns
• Experience in multi-step organic synthesis, with a proven ability to design and execute complex synthetic routes toward drug-like small molecules
• Experience in medicinal chemistry optimization: SAR, PK/PD, and strong working knowledge of DMPK principles
• Experience in chemical biology techniques including mammalian cell culture, cell-based assays (e.g. cytotoxicity, transfections, stable cell line generation, co-IP), and PPI assays (e.g. BRET, APEX/Bi

Nice to have

• Industry experience
• Computational chemistry experience
• HTS and phenotypic assay development
• Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
• Computational or molecular dynamics drug discovery experience
• DEL experience
• Experience managing synthetic chemistry CRO teams
• Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage
• One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Meditation retreats
• Reading budget

About the company

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). The company uses an OmniTAC drug discovery engine to furnish molecules that co-opt existing cellular machinery.