Scientist/Sr. Scientist, DMPK

The role

You will lead the drug metabolism and pharmacokinetics function by designing and executing DMPK studies across a small molecule portfolio. You will interpret data, support regulatory activities, and collaborate with medicinal chemistry, structural biology, pharmacology, and toxicology teams to advance programs from lead optimization through IND.

What you will do

• Design, execute, and interpret in vitro ADME studies
• Contribute to in vitro–in vivo correlation (IVIVC) analyses
• Interpret metabolic soft spot and MetID data
• Support CRO relationships for outsourced ADME studies
• Support bioanalytical activities including LC-MS/MS method development
• Design and support in vivo PK studies across rodent and non-rodent species
• Perform PK data analysis using Phoenix WinNonlin or equivalent
• Perform PK/PD modeling and simulation including PBPK modeling
• Support DMPK execution for IND-enabling programs and author study reports
• Contribute to DMPK sections of IND and CTA submissions

Required qualifications

• PhD in pharmacokinetics, pharmaceutical sciences, or a related discipline
• Minimum of 3 years of industry experience in DMPK
• Track record of contributing to small molecule programs
• Ability to work independently and collaborate within cross-functional project teams
• Hands-on expertise in in vitro ADME and in vivo PK
• Proficiency in PK data analysis (Phoenix WinNonlin or equivalent)
• Familiarity with PBPK/PK-PD modeling platforms (Simcyp, GastroPlus, or equivalent)
• Experience contributing to IND-enabling DMPK studies and authoring study reports
• Working knowledge of FDA, EMA, and ICH guidance relevant to DMPK
• Strong communication and presentation skills
• Hands-on experience with bioanalytical activities including LC-MS/MS method development
• Working knowledge of clinical pharmacology principles

Nice to have

• Experience working in a startup or early-stage biotech environment
• Experience contributing to a small molecule program advancing toward or through IND
• Experience with novel modalities such as TPD, molecular glues, or PROTACs
• Familiarity with AI/ML-based ADME prediction tools

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage
• One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Meditation retreats
• Reading budget

About the company

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs) using an OmniTAC drug discovery engine.