Senior Engineer III, ADME

The role

The Senior Engineer III, ADME will design, develop, and validate high-throughput in vitro ADME assays. This person will perform mass spectrometry analysis and provide data to guide lead optimization in the drug discovery pipeline.

What you will do

• Design, develop, optimize, and validate high-throughput in vitro ADME assays
• Perform mass spectrometry analysis of samples from ADME assays
• Ensure proper sample preparation and management for high-throughput analysis
• Analyze, interpret, and report complex ADME data
• Present results and provide expert recommendations to medicinal chemists and project teams
• Maintain detailed and accurate laboratory records, SOPs, and electronic notebooks
• Lead day-to-day operations of the ADME team
• Build and maintain SOPs, runbooks, checklists, and QC dashboards
• Collaborate with computational and data teams on metadata schemas and QC metrics
• Provide technical leadership and day-to-day guidance for scientists on ADME workflows

Required qualifications

• Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or a related field with 7+ years of relevant industry experience, or a Master's degree with 12+ years of industry experience
• Extensive, hands-on experience with LC-MS or acoustic MS particularly in a high-throughput setting
• Proven track record in developing and running automated in vitro ADME assays using state-of-the-art laboratory automation
• Strong theoretical and practical knowledge of drug metabolism pathways and DMPK
• Familiarity with common ADME prediction software and data visualization tools

Nice to have

• Experience using lab automation
• Programmatic coding experience (e.g., Python, R, or similar)
• Data visualization (Spotfire, Python, R, or similar)

Benefits

• company stock awards
• medical, dental & vision coverage
• health spending accounts
• voluntary benefits
• leave of absence policies
• 401(k) program with employer contribution
• 8 paid holidays
• full-week winter shutdown
• unlimited Paid Time Off policy

About the company

Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more. Their bioengineers make use of an in-house automated foundry for designing and building new organisms.