Staff / Senior Scientist, Assay Research

The role

You will design, plan, and execute experiments to improve the efficiency, accuracy, and scalability of the ProSE process. You will establish novel assay workflows and develop proxy assays to predict multi-cycle performance.

What you will do

• Design, plan, and execute experiments to improve the ProSE process.
• Establish novel assay workflows and determine requirements for novel components.
• Develop proxy assays to predict multi-cycle performance.
• Propose, design, and test novel analytical approaches to optimize the ProSE sequencing process.
• Correlate assay findings to physical characteristics of the system using multimodal characterization.
• Identify, communicate, and help address experimental risks or resource gaps.
• Partner with the Assay Development team to deliver goals and prioritize experiments.
• Collaborate with Chemistry, Assay Integration, Automation and Bioinformatics teams.
• Collect, manage, and analyze data from molecular biology and protein sequencing experiments.
• Keep a detailed electronic lab notebook on Confluence.

Required qualifications

• Post-graduate experience in molecular biology, biochemistry, chemistry or related fields.
• BS/MS/PhD with 10+ years (for Staff Scientist).
• BS/MS/PhD with 8+ years (for Senior Scientist).
• Track record of establishing novel assay workflows for highly sensitive molecular assays.
• Hands-on history of defining requirements for new components.
• Ability to design simple, mechanistically defined test systems.
• Comprehensive understanding of molecular biology tools used for high-sensitivity applications.
• Strong foundation in nucleic acid and peptide chemistry.
• Fluency in multimodal characterization.
• Excellent problem-solving skills and strong attention to detail.
• Excellent written and verbal communication skills.

Nice to have

• Hands-on experience with nanopore or other single-molecule detection platforms.
• Experience with statistical analysis of mixed-effects and replicated data.
• Experience with LC-MS and HPLC for characterizing biomolecules.
• Experience with bead-based automation on instruments such as KingFisher or Hamilton.
• Familiarity with accelerated or repeated-exposure stability testing.
• Familiarity with emerging trends and techniques in proteomic measurements.

Benefits

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities

About the company

Glyphic Biotechnologies is developing a massively parallel, single-molecule proteome sequencing platform. They have raised >$80M to achieve their vision of next generation proteome sequencing.