Scientist / Senior Scientist, Assay Integration (Reagents)

The role

The Scientist or Senior Scientist will build and sustain the reagent supply infrastructure for a single-molecule proteome sequencing platform. This role involves managing the full reagent lifecycle from formulation and characterization to stability qualification and QC method development.

What you will do

• Lead assay reagent development including formulation, characterization, and optimization.
• Characterize reagent performance using design-of-experiments approaches.
• Design and execute reagent storage stability studies.
• Build and implement a QC and control framework for platform reagents.
• Develop, qualify, and transfer QC test methods.
• Qualify each reagent lot prior to use in multi-cycle or KOL runs.
• Maintain batch records and quality documentation.
• Establish and maintain SOPs for assay reagents and integrated workflows.
• Forecast and maintain end-to-end reagent inventory.
• Partner with the Automation team to implement and qualify reagent-dependent assay steps.

Required qualifications

• Degree in Biochemistry, Chemical Biology, Biophysics, Biomedical Engineering, or an equivalent field
• PhD / MS / BS with 4+ / 6+ / 8+ years of relevant experience (Senior Scientist)
• PhD / MS / BS with 2+ / 4+ / 6+ years of relevant experience (Scientist II)
• Proven bench expertise in reagent development or analytical science
• Hands-on experience across biochemical characterization techniques and reagent classes including oligonucleotides, proteins, buffers, and solvents
• Ability to establish operating bounds and guard bands for critical reagent and process parameters
• Deep understanding of reagent formulation principles and their influence on stability and functional performance
• Practical experience across the full reagent development cycle including formulation, stability studies, and QC method development
• Experience working with chemically reactive or environmentally sensitive compounds
• Strong experimental design skills with the ability to plan and execute DOE-informed studies
• Experience developing reagents for multistep, integrated assay workflows
• Experience establishing and maintaining robust SOPs for end-to-end integrated workflows

Nice to have

• Background in proteomics reagents, protein modification chemistry, peptide-oligonucleotide conjugates, or single-molecule assay components
• Experience with automation platforms for liquid handling (e.g., Hamilton, ThermoFisher, Agilent) and protocol validation on automated workcells

Benefits

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities

About the company

Glyphic Biotechnologies is developing a massively parallel, single-molecule proteome sequencing platform to transform life science discovery. They have raised >$80M from venture partners and non-dilutive grant funding.