Principal Scientist, Chemical Development

The role

The Principal Scientist, Chemical Development will lead drug candidate process development programs and support small molecule linker-payload targets for ADCs. This role involves providing technical leadership, executing CMC regulatory strategies, and managing external partners.

What you will do

• Provide technical leadership as a key member of the chemical development team
• Function as the technical lead on at least one program
• Provide guidance and leadership to external partners
• Support programs at the bench as an individual contributor
• Devise and evaluate alternative routes of synthesis to reduce COGs and manufacturing lead times
• Develop data packages for technical transfer to external CMOs
• Carry out analytical data collection and oversight of external partner data
• Contribute to authoring regulatory documents like IND, IMPD, and NDA
• Execute integrated CMC regulatory strategies
• Collaborate with research, regulatory affairs, and CMC teams

Required qualifications

• PhD in Synthetic Organic Chemistry or similar with a minimum of 7 years of industry experience leading small molecule and/or linker-payload programs, or equivalent combination of education and experie
• Ability to travel domestically and internationally (5-15%)
• Ability to design cost effective robust manufacturing processes for complex small molecule targets
• Ability to troubleshoot and solve complex technical challenges quickly
• Collaborative and open-minded attitude
• Meticulous and detail-oriented scientist
• Proficient in generating and evaluating robust and reliable analytical data
• Proficient in writing technical reports and formulating presentations
• Ability to develop cross functional relationships with discovery chemistry and other pre-clinical groups
• Experience in leading and managing technology transfers to third party process development and manufacturing partners
• Knowledge of cGMP requirements and ICH guidelines related to CMC small molecule drug-substance development and manufacturing
• Track record of working closely with cross-functional teams in a biopharmaceutical or pharmaceutical environment

Nice to have

• Experience as a technical lead overseeing tech transfer, process development and implementation of processes for manufacture at internal and/or external manufacturers

Benefits

• Medical, dental, and vision insurance coverage for employees and their dependents
• 100% company-paid medical premiums for employees
• 401(k) with employer match
• Employer-paid life insurance, short- and long-term disability insurance, and AD&D
• Paid time off
• Company holidays
• A week-long winter break between Christmas and New Years
• Paid parental leave

About the company

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. The company is advancing an innovative portfolio of therapeutics, including antibody-drug conjugates.