Research Leader / Senior Scientist (In vivo Pharmacology & Translational Sciences), Cambridge, MA

The role

This person will design and implement translational strategies and in vivo pharmacology assessments for small molecule drug discovery. They will work with ML and drug discovery experts to validate biological hypotheses and advance oncology and immunology portfolios toward clinical phases.

What you will do

• Oversee planning, methodology, fiscal management, and implementation of in vitro and in vivo pharmacology, PK/PD, and safety assessments.
• Design translation strategies using datasets and biomarkers to inform patient selection frameworks.
• Define model paradigms including in vivo and ex vivo patient-derived tissue for translational packages.
• Work with CROs to design decision-making experiments and deliver biological data.
• Provide scientific expertise to ML and computational biology teams.
• Distill biological data into insights for project leaders and partners.
• Analyze and interpret experimental data to support IND regulatory filings and go/no-go decisions.
• Collaborate with ML, Discovery Biology, DMPK, Toxicology, and Clinical Development teams.
• Manage and mentor a team of 2-3 In vivo Pharmacologists for certain roles.

Required qualifications

• Ph.D. in Pharmacology, Immunology, Cancer Biology, Molecular Biology, or a related scientific discipline.
• 8+ years or 5+ years of professional experience in a Translational Sciences role within biotech, pharma or CRO.
• Experience of project leadership or leading biology within small molecule drug discovery programs.
• For people management positions, experience of leading a high-performing scientific team.
• Deep understanding of target, mechanism, and disease interdependencies.
• Expert knowledge of innovative translational models in oncology and/or immune disorders.
• Extensive pharma/biotech experience developing Target Product Profiles (TPPs) and biological screening cascades.
• Proven track record in constructing translational data packages and biomarker strategies.
• Experience in designing PK/PD experiments for human dose prediction.
• Proven track record managing multi-vendor CRO networks.
• Exceptional project management and leadership skills.

Nice to have

• Track record of driving strategic de-risking and SAR strategies.
• Good understanding of medicinal chemistry concepts.
• General knowledge of machine learning modelling applied to biological systems and drug discovery.

About the company

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. The company uses AI models to accelerate scientific discovery and design novel molecules.