Isomorphiclabs
Research Leader / Senior Scientist (DMPK), London
London. Posted 17 days ago
The role
DMPK Leads drive the DMPK strategy of drug discovery projects to deliver high quality clinical candidates. You will use and contribute to the optimisation of state-of-the-art computational and AI ADME models.
What you will do
- Design and implement stage-appropriate DMPK strategies with AI-first approach
- Design screening cascade and mechanistic experiments to support project progression
- Integrate DMPK, PD and toxicological data to extract decision-making information
- Define Quantitative Pharmacology strategy in collaboration with Pharmacology Leads
- Optimise the use of Iso’s datasets to address fundamental DMPK questions
- Optimise molecule design based on physico-chemistry and biotransformation knowledge
- Maintain knowledge of state-of-the-art technologies and methods
- Author DMPK sections of regulatory documents
- Embrace and champion a culture of inclusion and continuous professional development
Required qualifications
- PhD in either Pharmaceutical Science, Pharmacy, Chemistry, or another relevant subject
- 8+ years’ professional experience as a DMPK Lead
- Experience in supporting DMPK across multiple modalities
- Comprehensive understanding of drug metabolism, pharmacokinetics, PKPD principles, and translational research
- Practical experience developing DMPK and quantitative pharmacology packages to support early clinical development
- Experience in authoring and reviewing regulatory documents
- Experience of partnering closely with Preclinical and Clinical teams
- Demonstrated cross-functional leadership
- Exceptional interpersonal, communication, and collaborative problem-solving capabilities
- In depth knowledge of biotransformation
- Experience of utilising and applying NAMs to further project understanding
- Strategic thinker with strong communication skills
Nice to have
- Advanced knowledge of PKPD modelling
- Good understanding of machine learning techniques
- Familiarity with R, Python and KNIME
About the company
Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. The company uses AI to model complex biological phenomena to help design novel molecules and develop innovative medicines.