Research Leader (Toxicology), London

The role

You will own the safety assessment strategy for specific drug discovery and development projects. You will guide the development of an AI predictive toxicology platform and manage relationships with external CROs.

What you will do

• Tailor and implement project-specific safety assessment strategies with an AI-first approach.
• Design screening cascades and mechanistic experiments to mitigate safety risks.
• Provide technical expertise to develop SAR understanding of toxicology liabilities.
• Define regulatory safety assessment packages for regulatory agencies.
• Communicate integrated risk assessments and recommendations to internal stakeholders.
• Author and defend toxicology sections of regulatory documents.
• Maintain and develop relationships with the CRO network.
• Oversee the delivery of data generation campaigns for AI-based toxicology models.
• Empower team members by sharing toxicology expertise.

Required qualifications

• PhD in Toxicology, Pharmacology, Biology, or related technical field, or equivalent industrial experience.
• 8+ years of professional experience working in a senior toxicology role within a biotech or pharma setting.
• Proven track record of delivering successful non-clinical safety strategies as a project representative across different therapy areas.
• Demonstrated experience designing, implementing and filing successful IND packages for both small molecules and biologics.
• Deep understanding of Global Regulatory Guidelines regarding safety assessment.
• Experience of partnering closely with Discovery and Clinical teams.
• Excellent communication (written and verbal), interpersonal and influencing skills.
• Ability to work effectively in a cross-functional, collaborative team environment.
• Track record of creative problem solving with a strong growth mindset, adaptability, willingness to challenge conventional thinking and eagerness to learn new concepts.

Nice to have

• Board certification
• Experience with peptides and other new modalities.
• Good understanding of the application of AI/ML techniques in drug discovery

About the company

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. The company uses AI to model complex biological phenomena to design novel molecules and develop innovative medicines.