Senior Research Investigator (Biologics Computational Science), London

The role

You will contribute to the design of novel large molecule therapeutics using an AI drug design engine. You will work with machine learning and biologics discovery teams to develop computational methods and analyze lab data.

What you will do

• Identify opportunities for computational modelling to enhance biologics discovery programs.
• Develop new methods for computational modelling.
• Collaborate with machine learning and biologics discovery teams to develop methods for predicting biologics properties from sequence.
• Apply computational methods to discover novel therapeutics.
• Benchmark existing computational methods and develop baseline models.
• Analyse data from lab experiments to inform decisions for biologics discovery programs.
• Determine what data to generate to improve machine learning models.
• Implement model-aware prioritization to ensure collecting high-value data points.
• Develop methods for predicting functional properties of biologics expressed in terms of biophysical constraints.

Required qualifications

• Experience using computational and machine learning methods to predict biologics properties.
• Experience developing computational methods to predict biologics properties from sequence, such as affinity, developability or immunogenicity.
• PhD or equivalent in computer science, computational biology, structural biology, biochemistry or related field.
• Proficient programming skills with a strong emphasis on Python.
• Experience preparing datasets, benchmarking models, and working with structure-based metrics.
• Comfortable learning new ways of working in fast changing environments

Nice to have

• Industry experience in a pharma or biotech environment.
• Experience working in multidisciplinary large molecule drug discovery teams.
• Experience with structural modelling of biologics, including 3D protein structure tools.
• Experience using generative-design methods for biologics.
• Experience working with complex biologics modalities, such as antibody-drug conjugates (ADC’s) or multispecifics.

About the company

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. The company uses AI to model complex biological phenomena to help design novel molecules and develop innovative medicines.