Medicinal Drug Design Lead, London

The role

You will act as a Chemistry Lead to deliver scientific expertise and strategic direction for portfolio projects. You will drive drug discovery programs using modern discovery principles and synthetic organic chemistry while collaborating with AI/ML platform teams.

What you will do

• Invent new medicines and drive drug discovery programs to value inflection points.
• Collaborate cross-functionally to support data-driven scientific solutions.
• Provide strategic input and technical direction to AI/ML platform teams.
• Represent the company externally with collaborators and CROs.
• Manage CRO resources and monitor KPIs.
• Prepare detailed scientific proposals and reports.
• Support and mentor junior colleagues.

Required qualifications

• PhD in Medicinal Chemistry, Synthetic Organic Chemistry, or a related technical field, or equivalent industrial experience.
• 5+ years professional experience in a Medicinal Chemistry role within a biotech, pharma or CRO setting.
• Proven track record of leading medicinal chemistry efforts on drug discovery projects.
• Familiarity of optimisation of DMPK.
• Experience of contributing to structure-based drug design problems.
• Excellent strategic thinking, problem-solving, and decision-making capabilities.
• Experience of working with and closely managing CRO resources.
• Strong track record of scientific achievements evidenced by publications, patents, and presentations.
• Passion for drug discovery and enthusiasm for the potential of AI/ML.
• Excellent communication and interpersonal skills.
• Track record of creative problem solving with a strong growth mindset and adaptability.

Nice to have

• Applied advanced experimental and AI-driven hit identification methods.
• Previous experience with hit-finding strategies for challenging targets.
• Experience with different therapeutic modalities like ADCs, peptides, degraders and other proximity inducers.

About the company

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. The company uses AI models to model complex biological phenomena to help design novel molecules and develop innovative medicines.