Scientist, Drug Metabolism and Pharmacokinetics (DMPK)

The role

This person will generate high-quality ADME/PK data to support a small molecule drug pipeline. They will perform bioanalysis, develop in vitro assays, and use mass spectrometry.

What you will do

• Develop in vitro assays and generate high quality data
• Perform bioanalysis of small molecules using liquid chromatography and mass spectrometry
• Execute, analyze, and interpret in vitro drug metabolism assays
• Culture, test, and validate cell or assay systems
• Perform bioanalysis of pharmacokinetic samples and determine pharmacokinetic parameters
• Maintain laboratory notebooks, protocols, and reports
• Present data in team and project meetings
• Maintain and manage research databases
• Develop and document assay protocols for chemistry, biology, and DMPK studies
• Upload, organize, and QC assay data

Required qualifications

• Ph.D. in pharmaceutical sciences, chemistry, bioanalysis, or biomedical science related fields with 0 – 3 years of experience
• Or at least 5 years (M.S. degree) industrial/ academia experience
• Or 8 years (B.S. degree) industrial/ academia experience
• Excellent verbal and technical communication
• Independent thinking
• Ability to interpret results, determine next steps and present data
• Ability to work in a team oriented, innovative and fast-paced environment
• Experience in development of LC-MS-based analytical methods and sample preparation for small molecule analysis
• Hands-on experience in culturing primary and recombinant cell lines
• Developing cell-based and in vitro drug metabolism assays

Nice to have

• Experience as a project representative
• Proficient in operation, maintenance and troubleshooting for high end scientific instrumentation, including general liquid handling equipment, Thermo Orbitrap Q-Exactive, Exploris 240 HRAMS, Sciex or
• Prior experience and knowledge in drug metabolism assays (i.e. metabolic stability assays in liver microsomes and hepatocytes, protein binding, cytochrome P450 inhibition assays and bioanalysis of PK
• PK modeling programs such Phoenix Winnonlin, SimCyp
• DMPK concepts to support ADME studies
• Experience with research databases (e.g. CDD Vault)

About the company

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. The co-founders previously led MyoKardia to discover and develop mavacamten.