Executive Director, Global Program Leader

The role

The Executive Director, Global Program Leader is responsible for the development, execution, and governance of in vivo CAR-T programs. This role leads cross-functional teams to execute integrated global development strategies from IND enabling through lifecycle management.

What you will do

• Lead the overall strategy and execution of assigned in vivo CAR-T programs across the development lifecycle.
• Develop and maintain integrated global development plans.
• Serve as the primary strategic leader and accountable executive for program success, timelines, budgets, and milestones.
• Drive portfolio decision-making by evaluating benefit-risk profiles and investment priorities.
• Lead the formulation and execution of global clinical development and registration strategies.
• Partner with Clinical Development and Regulatory Affairs to design development pathways.
• Guide critical regulatory interactions and major health authority milestones.
• Chair Global Program Teams and provide leadership across all functional areas.
• Present program strategies, risks, and recommendations to executive leadership.
• Represent Legend Biotech in interactions with external partners, collaborators, and stakeholders.

Required qualifications

• Minimum 10+ years of biotechnology or pharmaceutical industry experience in drug development.
• Minimum 5+ years of leadership experience managing complex, global development programs.
• Demonstrated success advancing biologics, cell therapies, gene therapies, or other advanced therapeutic programs through clinical development.
• Direct experience leading cross-functional development teams in a matrix environment.
• Experience supporting global regulatory interactions and major regulatory submissions.
• Deep understanding of global drug development, clinical development, and registration pathways.
• Strong knowledge of cell and gene therapy development, including emerging in vivo CAR-T technologies.
• Exceptional strategic thinking and portfolio management capabilities.
• Demonstrated ability to influence senior leaders and drive decisions in complex environments.
• Outstanding communication, presentation, and executive stakeholder management skills.
• Strong business acumen, financial awareness, and risk-management capabilities.
• Proven ability to lead diverse global teams and achieve ambitious development goals.

Nice to have

• Experience in oncology, immunology, cell therapy, gene therapy, or in vivo genetic medicines

Benefits

• Medical, dental, and vision insurance
• 401(k) retirement plan with a company match that vests fully on day one
• Eight (8) weeks of paid parental leave after three (3) months of employment
• Paid time off including vacation, personal, sick, floating holidays, and eleven (11) company holidays
• Flexible spending and health savings accounts
• Life and AD&D insurance
• Short- and long-term disability coverage
• Legal assistance
• Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
• Voluntary commuter benefits
• Family planning and care resources
• Well-being initiatives and peer-to-peer recognition programs

Before you apply

• Applicants must be authorized to work in the United States.
• Employment eligibility will be verified through E-Verify.

About the company

Legend Biotech is a global biotechnology company dedicated to treating and curing life-threatening diseases. The company is advancing the next generation of cell therapy through a portfolio of innovative technologies.