Senior Engineer / Principal Engineer, Vector Downstream

The role

The Senior Engineer / Principal Engineer, Vector Downstream will design, optimize, and scale purification processes for lentiviral vectors. This role focuses on delivering high-quality vector products to support LVV generation and advanced cell therapy programs.

What you will do

• Build mechanistic and hybrid models for LVV downstream processing.
• Apply engineering concepts like mass transfer, fluid mechanics, and thermodynamics to build in silico process models.
• Perform data analytics using ML algorithms for modeling and clustering.
• Implement development and optimization of downstream processes including clarification, chromatography, and TFF.
• Lead or support the translation of bench-scale processes to GMP manufacturing.
• Design and implement Advanced Process Control strategies.
• Communicate potential issues, delays, solutions, and mitigation approaches.
• Identify project acceleration opportunities with senior leaders.
• Maximize vector recovery, purity, and potency using advanced science and technology.
• Provide technical guidance and collaborate with scientists and cross-functional teams.

Required qualifications

• Advanced degree (MS) in Chemical Engineering, Biomedical Engineering, Bioprocess Engineering, or a related field.
• 6+ years (PhD) or 8+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
• Strong engineering knowledge of bioprocess modeling/simulation and the interaction of biomolecules, materials, and machinery.
• Strong technical experience in purification, chromatography, and TFF.
• Understanding of GMP manufacturing requirements and CMC strategies for clinical-stage product development.
• Strong communication, collaboration, leadership, and problem-solving skills.
• Creative and strategic thinking.
• Strong troubleshooting skills.
• English

Nice to have

• PhD preferred
• Experience with modeling software and programming languages such as Python and/or MATLAB
• Experience with lentiviral vector technologies
• Relevant viral vector, biologics, gene therapy, or advanced therapy process development experience
• Experience in developing vector processes tailored for in vivo CAR-T generation and systemic delivery
• Experience in large-scale (>50L) purification processes
• Mandarin

Benefits

• Medical, dental, and vision insurance
• 401(k) retirement plan with a company match that vests fully on day one
• Eight weeks of paid parental leave after three months of employment
• Paid time off including vacation, personal, sick, floating holidays, and eleven company holidays
• Flexible spending and health savings accounts
• Life and AD&D insurance
• Short- and long-term disability coverage
• Legal assistance
• Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
• Commuter benefits
• Family planning and care resources
• Well-being initiatives and peer-to-peer recognition programs

Before you apply

• Applicants must be authorized to work in the United States
• Employment eligibility will be verified through E-Verify

About the company

Legend Biotech is a global biotechnology company dedicated to treating and curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, the company advances cell therapy through a portfolio of innovative technologies.