Scientist, Molecular Assays

The role

This scientist will support the development, execution, and optimization of molecular assays for clinical, translational, and preclinical programs. Work focuses on quantitative PCR, digital droplet PCR, and next-generation sequencing.

What you will do

• Perform molecular biology experiments supporting clinical, translational, and preclinical research programs.
• Execute qPCR and ddPCR assays for gene expression analysis, biomarker quantification, transgene detection, vector copy number determination, and biodistribution studies.
• Support development, optimization, qualification, transfer, and troubleshooting of molecular assays.
• Perform nucleic acid extraction, quantification, and quality assessment from biological samples.
• Prepare samples and perform library preparation for next-generation sequencing (NGS) applications.
• Operate and maintain molecular biology instrumentation.
• Analyze experimental data and maintain accurate laboratory documentation.
• Process, track, and manage biological samples using LIMS and ELN systems.
• Support laboratory operations including inventory management and equipment maintenance.
• Contribute to the continuous improvement of laboratory workflows and assay performance.

Required qualifications

• M.S. in Life Sciences, Molecular Biology, Biochemistry, or a related field with 8+ years of relevant experience, or Ph.D. in a related scientific discipline with 3+ years of relevant experience.
• Hands-on experience with molecular biology techniques, including nucleic acid extraction, qPCR, RT-qPCR, and/or ddPCR.
• Experience with NGS workflows and library preparation.
• Familiarity with assay development, data analysis, and biological sample processing.
• Strong attention to detail, organization, and documentation skills.
• Excellent analytical, problem-solving, and communication skills.
• Ability to work independently and collaboratively in a fast-paced laboratory environment.
• Commitment to data quality, laboratory safety, and continuous learning.
• Work in a clinical, research, pharmaceutical, or diagnostic laboratory.
• May require standing for extended periods and lifting up to 25 pounds.
• Use of personal protective equipment (PPE) is required.
• Involve handling biological specimens and hazardous materials following safety guidelines.

Nice to have

• single-cell sequencing experience is a plus
• Experience in cell and gene therapy, immunology, oncology, or regulated laboratory environments is desirable

Benefits

• Medical, dental, and vision insurance
• 401(k) retirement plan with a company match that vests fully on day one
• eight (8) weeks of paid parental leave after just three (3) months of employment
• paid time off including vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
• flexible spending and health savings accounts
• life and AD&D insurance
• short- and long-term disability coverage
• legal assistance
• supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
• voluntary commuter benefits
• family planning and care resources
• well-being initiatives and peer-to-peer recognition programs

Before you apply

• Applicants must be authorized to work in the United States.
• Participation in the E-Verify program.
• Required to complete the Form I-9 process.

About the company

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, the company advances the next generation of cell therapy through a portfolio of innovative technologies.