Lilasciences
Staff/Principal Engineer, Search & Retrieval
San Francisco, CA USA. Posted 18 days ago
The role
This person will own the search and retrieval stack for scientific knowledge, including RAG over unstructured text and a scientific knowledge graph. They will build the infrastructure for how scientists and agents ask questions of literature, patents, and lab protocols.
What you will do
- Provide technical leadership across platform engineering, infrastructure, AI/ML, and scientific teams.
- Define the shared retrieval foundation and architecture for scientific workloads.
- Build a scientific knowledge graph from literature and the structured experimental record.
- Own graph retrieval and its fusion with vector and lexical search.
- Build the autonomous research loop through agentic search.
- Own the retrieval pipeline end to end and the evaluation harness.
- Own the pipeline that turns scientific data into semantically searchable evidence.
Required qualifications
- 8+ years of software development experience, including production ownership of a search, retrieval, RAG, or knowledge graph system.
- Production experience building semantic search: embedding models, vector indexes (HNSW/IVF), hybrid lexical and vector retrieval, and reranking.
- Track record in high-growth environments.
- Ability to describe how retrieval quality was measured and how regressions were caught.
- Hands-on coding in Python and modern backend frameworks (FastAPI, async Python).
- Modern cloud-native architectures (Kubernetes, Terraform, AWS).
- Strong cross-functional communication and the ability to influence architecture across teams.
- BS, MS, or Ph.D. in Computer Science or a related field of study, or equivalent experience.
Nice to have
- Shipped RAG or semantic search in a regulated or enterprise context (SOC 2, HIPAA, GxP, or FedRAMP).
- Permission-aware retrieval over access-controlled data.
- Document understanding at scale: OCR, layout-aware parsing, table and figure extraction.
- Agentic retrieval and GraphRAG patterns.
- Platforms serving scientific or laboratory data such as LIMS, ELN, bioinformatics, or materials informatics.
- Domain-specific corpora and scientific ontologies (UMLS, MeSH, ChEBI, GO, UniProt, Materials Project).
- Knowledge graph construction and graph retrieval: property graph or RDF stores.
- Graph database experience
Benefits
- Medical, dental, and vision coverage
- Employer-paid life and disability insurance
- Flexible time off with generous company wide holidays
- Paid parental leave
- Educational assistance program
- Commuter benefits, including bike share memberships for office based employees
- Company subsidized lunch program
About the company
Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. The company builds systems that can learn for themselves by combining advanced AI models with proprietary AI Science Factory™ instruments.