Lilasciences

Staff/Principal Engineer, Search & Retrieval

San Francisco, CA USA. Posted 18 days ago

The role

This person will own the search and retrieval stack for scientific knowledge, including RAG over unstructured text and a scientific knowledge graph. They will build the infrastructure for how scientists and agents ask questions of literature, patents, and lab protocols.

What you will do

  • Provide technical leadership across platform engineering, infrastructure, AI/ML, and scientific teams.
  • Define the shared retrieval foundation and architecture for scientific workloads.
  • Build a scientific knowledge graph from literature and the structured experimental record.
  • Own graph retrieval and its fusion with vector and lexical search.
  • Build the autonomous research loop through agentic search.
  • Own the retrieval pipeline end to end and the evaluation harness.
  • Own the pipeline that turns scientific data into semantically searchable evidence.

Required qualifications

  • 8+ years of software development experience, including production ownership of a search, retrieval, RAG, or knowledge graph system.
  • Production experience building semantic search: embedding models, vector indexes (HNSW/IVF), hybrid lexical and vector retrieval, and reranking.
  • Track record in high-growth environments.
  • Ability to describe how retrieval quality was measured and how regressions were caught.
  • Hands-on coding in Python and modern backend frameworks (FastAPI, async Python).
  • Modern cloud-native architectures (Kubernetes, Terraform, AWS).
  • Strong cross-functional communication and the ability to influence architecture across teams.
  • BS, MS, or Ph.D. in Computer Science or a related field of study, or equivalent experience.

Nice to have

  • Shipped RAG or semantic search in a regulated or enterprise context (SOC 2, HIPAA, GxP, or FedRAMP).
  • Permission-aware retrieval over access-controlled data.
  • Document understanding at scale: OCR, layout-aware parsing, table and figure extraction.
  • Agentic retrieval and GraphRAG patterns.
  • Platforms serving scientific or laboratory data such as LIMS, ELN, bioinformatics, or materials informatics.
  • Domain-specific corpora and scientific ontologies (UMLS, MeSH, ChEBI, GO, UniProt, Materials Project).
  • Knowledge graph construction and graph retrieval: property graph or RDF stores.
  • Graph database experience

Benefits

  • Medical, dental, and vision coverage
  • Employer-paid life and disability insurance
  • Flexible time off with generous company wide holidays
  • Paid parental leave
  • Educational assistance program
  • Commuter benefits, including bike share memberships for office based employees
  • Company subsidized lunch program

About the company

Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. The company builds systems that can learn for themselves by combining advanced AI models with proprietary AI Science Factory™ instruments.

Staff/Principal Engineer, Search & Retrieval at Lilasciences | JobZoey