Staff Scientist, Research (Oncology Diagnostics)

The role

The Staff Scientist will lead the research and development of novel next-generation sequencing (NGS) technologies. This role involves designing and optimizing high-complexity NGS methods to advance the oncology diagnostic portfolio.

What you will do

• Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization.
• Define project goals and plans and manage multiple project streams in parallel.
• Design and execute complex laboratory experiments.
• Analyze and interpret results to guide research direction.
• Coordinate cross-functional efforts with bioinformatics, statistics, and data science teams.
• Mentor and guide junior scientists.
• Author high-quality protocols, technical reports, and study documentation.
• Communicate progress to stakeholders and senior leadership.
• Contribute to risk management, strategy development, and continuous improvement of scientific workflows.

Required qualifications

• Ph.D. in molecular biology, genomics, or a closely related field.
• Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry.
• Proven experience in designing and advancing NGS-based diagnostics.
• Strong technical foundation in molecular biology or chemistry.
• Deep mechanistic knowledge of NGS library preparation chemistry.
• Demonstrated ability to independently design and execute complex experiments (solid DOE skills).
• Creativity and ingenuity in solving high-ambiguity technical challenges.
• Experience leading research projects in an industrial setting.

Nice to have

• Experience with cfDNA or liquid biopsy assay development.
• Hands-on experience with NGS-based methylation detection and epigenomic workflows.
• Familiarity with translating early-stage research assays toward regulated product environments.
• Proficiency in statistical analysis tools such as Excel, JMP, R, or Python.
• Familiarity with bioinformatics workflows

Benefits

• Annual performance incentive bonus
• Long-term equity awards
• Comprehensive health benefits (medical, dental, vision)
• 401(k) with company match
• Generous paid time off and company holidays
• Life and disability plans
• Free testing for employees and immediate families
• Fertility care benefits
• Pregnancy and baby bonding leave
• Commuter benefits

About the company

Natera is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. The company aims to make personalized genetic testing and diagnostics part of the standard of care.