Newlimit
Scientist/Senior Scientist, Immunology
South San Francisco. Posted 9 months ago
The role
This person will lead and execute discovery-to-preclinical research efforts in inflammatory and autoimmune diseases. They will design in vitro screening assays and conduct in vivo and in vitro immunology studies focusing on T cell and regulatory T cell biology.
What you will do
- Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design and evaluate epigenetic reprogramming interventions
- Develop scalable functional assays in T cells and Tregs to predict therapeutic activity
- Design and lead in vivo and in vitro immunology studies to support target discovery, validation, and preclinical development
- Contribute expertise in inflammatory and autoimmune disease biology to experimental design and program strategy
- Drive research in Treg biology, including differentiation, stability, and suppressive function
- Author or contribute to study reports, internal data packages, and regulatory-supporting documentation
- Mentor junior scientists
- Present data, analyses, and scientific recommendations to internal teams and leadership
Required qualifications
- Ph.D. in immunology, cell biology, or a related field or BS/MS with 6+ years of relevant industry experience
- Hands-on experience with multi-parameter flow cytometry
- Experience designing in vivo models of autoimmune or inflammatory disease
- Experience with primary immune cell isolation, ex vivo culture, and Treg functional assay
Nice to have
- Experience with pooled in vitro or in vivo screening approaches using bulk or single-cell readouts (e.g., CRISPR fitness screens, Perturb-seq, CROP-seq)
- Experience with rheumatoid arthritis and/or colitis models
- Experience authoring IND-supporting study reports
- Experience managing or partnering with CROs to support preclinical studies
- Familiarity with basic computational tools for data analysis (e.g., Python, R)
Benefits
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- 20 days/year PTO plus holidays
- Meals and snacks on-site
About the company
NewLimit is a biotechnology company working to radically extend human healthspan. They develop medicines to treat age-related diseases by reprogramming the epigenome.