Scientist I, Medicinal Chemistry

The role

You will design and synthesize novel small molecules for patients with unmet medical needs. You will work as part of a multidisciplinary project team using structure-based drug design.

What you will do

• Design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy
• Engage in rational structure-based drug discovery
• Apply problem-solving skills to troubleshoot challenges and identify practical solutions
• Design and execute high-quality experiments and analyze results
• Advance structure-activity relationship (SAR) studies
• Collaborate with scientists in computational chemistry, structural biology, biochemistry, biophysics, cellular biology, pharmacology, DMPK, and toxicology
• Stay current with advances in synthetic and medicinal chemistry
• Communicate scientific rationale, results, challenges, and recommendations to colleagues and cross-functional teams

Required qualifications

• PhD with up to 4 years of relevant experience, MS with 6 or more years of relevant experience, or BS or equivalent with 10 or more years of relevant experience
• Strong expertise in synthetic organic chemistry
• Demonstrated ability to design and execute complex, multistep organic synthesis
• Strong scientific and synthetic problem-solving skills
• Ability to independently troubleshoot challenging chemistry
• Scientific curiosity and creativity
• Ability to rapidly learn and apply new concepts, technologies, and approaches
• Strong interpersonal and teamwork skills
• Ability to contribute in a collaborative, multidisciplinary research environment
• Excellent written and verbal communication skills
• Knowledge of medicinal chemistry principles, structure-based drug design, pharmacology, and/or ADME/PK

About the company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines. The company aims to establish degrader-based treatments for cancer and inflammatory diseases.