Senior Scientist, Medicinal Chemistry

The role

You will drive medicinal chemistry strategy for discovery programs from hit optimization through development candidate nomination. You will design novel compounds and interpret complex SAR across multidisciplinary datasets.

What you will do

• Design novel chemical entities and medicinal chemistry strategies
• Design synthetic strategies for complex molecules using modern and creative synthetic methods
• Develop and interpret SAR by integrating chemical, structural, computational, biochemical, cellular, pharmacological, and ADME/PK data
• Partner closely with computational chemists, structural biologists, and colleagues across biology, pharmacology, and DMPK
• Develop innovative concepts to establish new directions and address complex challenges
• Lead chemistry workstreams within multidisciplinary teams
• Manage priorities and external collaborations
• Provide scientific guidance, coaching, and mentorship to other scientists
• Communicate scientific rationale, data, and recommendations to project teams and leadership
• Contribute to intellectual property generation, patent preparation, and scientific publications

Required qualifications

• BS or MS with 14+ years of relevant experience, or PhD with 8+ years of relevant experience
• Strong expertise in medicinal chemistry and synthetic organic chemistry
• Demonstrated ability to apply synthetic strategies to complex discovery challenges
• Ability to integrate potency, selectivity, structural, physicochemical, ADME/PK, and pharmacology data
• Solid understanding of biology and pharmacology
• Scientific creativity and a track record of innovation
• Strong problem-solving and project management skills
• Ability to establish new chemical, scientific, or strategic directions from experimental data, structural insights, literature, and patents
• Experience providing scientific guidance, coaching, or mentorship
• Excellent written and verbal communication skills

About the company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines. The company uses an AI-integrated discovery engine and ligase expertise to develop treatments for cancer and inflammatory diseases.