Senior Research Associate, Preclinical Pharmacology

The role

You will run in vivo studies to move degrader programs toward the clinic. You will execute mouse efficacy, PK/PD, and mechanism-of-action studies in oncology and inflammation models and generate Western blot and flow cytometry data.

What you will do

• Perform mouse handling and in-life procedures including dosing, tumor implantation, and blood collection
• Execute PK/PD, tolerability, and efficacy studies in oncology and inflammation models
• Prepare and formulate test articles and vehicles for dosing
• Monitor animal health and document observations
• Perform necropsy and collect, process, and bank tissues and blood
• Perform Western blotting to measure target degradation and pathway modulation
• Develop, run, and analyze multi-color flow cytometry panels
• Maintain and expand cell lines using sterile cell culture technique
• Record experiments in the electronic lab notebook and present results
• Collaborate with Biology, Chemistry, DMPK, and Translational teams

Required qualifications

• BS/MS in Biology, Pharmacology, Immunology, Cancer Biology, or a related field
• BS or equivalent plus 8 or more years of relevant experience, or an MS plus 4 or more years of relevant experience
• Industry (biotech or pharma) experience conducting in vivo pharmacology studies in mice
• Proficiency in mouse handling and dosing by PO, IP, SC, and IV routes, as well as blood collection and tissue harvest
• Hands-on experience with oncology models (e.g., xenograft, syngeneic) and with murine models of inflammation or immunology
• Demonstrated proficiency in Western blotting and flow cytometry, including sample preparation, staining, and data analysis
• Proficiency in sterile mammalian cell culture technique
• Working knowledge of IACUC regulations and humane animal care practices
• Strong organizational and documentation skills
• Ability to work in an animal facility and tolerate exposure to laboratory animals
• Ability to work occasional weekends or off-shift hours as studies require

Nice to have

• experience with targeted protein degradation (molecular glues, PROTACs) or other small-molecule oncology or immunology programs
• experience with multi-spectral flow cytometry, automated Western (e.g., Jess/Wes), ELISA, or MSD cytokine/biomarker assays
• experience with orthotopic, disseminated, PDX, or humanized mouse models, or with in vivo imaging
• experience with inflammation models such as collagen-induced arthritis, colitis, or cytokine-challenge models
• familiarity with PK/PD relationships, compound formulation, and dose-response study design
• proficiency with GraphPad Prism and electronic lab notebook systems

About the company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines. The company uses an AI-integrated discovery engine to develop treatments for cancer and inflammatory diseases.