Senior/Principal Scientist, Medicinal Chemistry

The role

This person will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. They will engage in rational structure-based drug discovery and collaborate with a multi-disciplinary team.

What you will do

• Design and synthesize novel chemical entities
• Engage in rational structure-based drug discovery
• Collaborate with scientists within Nurix and external collaborators
• Contribute to patent, report and scientific publication writing
• Initiate and/or lead process improvements within the chemistry department or cross-functionally
• Direct drug discovery programs to phase transitions or series go/no go decisions
• Partner with computational chemists in the use of computational tools, models and visualization applications
• Manage priorities and advance multiple projects simultaneously

Required qualifications

• Ph.D. in synthetic organic chemistry
• 8 – 10+ years pharmaceutical medicinal chemistry industrial experience
• Track record of delivering advanced leads/ development candidates
• Excellent knowledge of medicinal chemistry principles with a solid understanding of the biology and pharmacology of programs, ADME concepts, and series SAR
• Strong working knowledge of protein-ligand interactions, conformational and structural analysis
• Experienced in partnering closely with computational chemists in the use of computational tools, models and visualization applications
• Expert in organic synthesis, knowledgeable of the current literature, with strong synthetic problem-solving skills
• Proven leadership capability in a cross-functional team setting, either as project team leader or co-lead
• Ability to make inventive contributions towards new chemical target structures or templates for programs and evaluate early screening or literature hits
• Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings
• Excellent communication skills and the ability to present rationale, key data, issues and accomplishments to the company
• Ability to manage priorities and advance multiple projects simultaneously

Nice to have

• Experience supervising direct reports to a high level of productivity and mentoring for career development

About the company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines. The company aims to establish degrader-based treatments at the forefront of patient care.