Senior Scientist / Principal Scientist, Induced Proximity

The role

This person will execute non-degradative induced proximity research strategies. They will design and run biochemical, biophysical, and cell-based assays to validate targets and characterize mechanisms.

What you will do

• Design, execute, and troubleshoot experiments at the bench
• Build and run biochemical, biophysical, and cell-based assays
• Contribute to identification, validation, and prioritization of targets
• Evaluate and integrate new and emerging induced proximity modalities
• Partner with computational/structural biology for rational design
• Present experimental data and recommendations to project teams and leadership
• Ensure programs meet key milestones from discovery to IND-enabling work
• Stay current on the competitive and scientific landscape

Required qualifications

• Ph.D. in biology, biochemistry, molecular biology, or a related field
• 5+ years of relevant industry drug discovery experience, including significant direct work on induced proximity modalities
• Hands-on biophysical and biochemical assay development to quantify ternary complex formation and cooperativity
• Experience in biochemical assay development of the relevant proximity-induced reaction
• Cell-based mechanistic pharmacology: Western blot, HiBiT/NanoLuc kinetic readouts, flow cytometry, reporter assays, and dose–response and washout/resynthesis studies
• Cell line engineering and functional genomics utilizing CRISPR knockout/knock-in, CRISPRa/CRISPRi, and siRNA
• Target engagement and protein-stability methods: CETSA, NanoBRET target engagement, co-IP/pulldown, and cycloheximide-chase or half-life measurement
• Deep mechanistic understanding of ternary complex biology and cooperativity, ubiquitin–proteasome and autophagy–lysosomal pathways, non-degradative proximity mechanisms, and structure-based drug desig
• Rigorous experimental design and quantitative data analysis
• Strong track record of cross-functional collaboration
• Excellent scientific communication skills

Nice to have

• Ph. D. in a relevant scientific field with 4 or more years of relevant post-graduate industry or academic research experience, or MS with 8 or more years of relevant industry experience
• Publication record and/or patents in induced proximity or targeted degradation space
• Experience with computational tools for ternary complex prediction or AI/ML-driven drug design
• Familiarity with a broad range of non-degradative modalities beyond classical bifunctional degraders

About the company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines. The company uses an AI-integrated discovery engine and ligase expertise to develop treatments for cancer and inflammatory diseases.