Director, Head of Investigative Toxicology

The role

You will build Nurix's in-house in vitro toxicology capability from the ground up. This hands-on, lab-based leadership role involves establishing assays and infrastructure to identify safety liabilities for targeted protein degrader programs.

What you will do

• Design, establish, and validate an in-house in vitro toxicology testing platform
• Develop and implement in vitro toxicology assays to screen for cytotoxicity and off-target liabilities
• Define the technical roadmap and prioritize in-house assays versus CRO sourcing
• Own day-to-day lab operations including equipment, vendor, and reagent management
• Serve as the in vitro/investigative toxicology representative on discovery project teams
• Design and interpret investigative studies to elucidate mechanisms of toxicity
• Partner with DMPK, Pharmacology, and Discovery Biology to integrate toxicology data into decisions
• Translate in vitro findings into risk assessments and recommendations
• Hire, mentor, and develop scientific staff
• Represent in vitro/investigative toxicology in Research Leadership meetings

Required qualifications

• PhD in Toxicology, Pharmacology, Molecular Biology, or a closely related life sciences discipline
• 10+ years of relevant nonclinical safety, investigative toxicology, or molecular/cellular toxicology experience in the pharmaceutical or biotechnology industry
• Direct, hands-on laboratory experience with in vitro and/or complex in vitro (MPS) model systems
• Demonstrated experience building, validating, and implementing new in vitro assay platforms or laboratory capabilities in an industry setting
• Strong working knowledge of mechanisms of drug-induced toxicity and the in vitro tools used to investigate them
• Proven ability to translate in vitro data into actionable risk assessments and communicate findings to cross-functional teams and leadership
• Experience managing CRO relationships and evaluating build-versus-buy decisions

Nice to have

• postdoctoral training
• Experience with targeted protein degradation (TPD) or other novel small molecule modalities
• Experience establishing or scaling a laboratory function within a growing, clinical-stage biotech
• Familiarity with New Approach Methodologies (NAMs) and organ-on-chip/microphysiological systems
• People management or mentoring experience
• Strong publication record in investigative or molecular toxicology

About the company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines. The company uses an AI-integrated discovery engine to develop treatments for cancer and inflammatory diseases.