Director of Chemistry, Manufacturing and Controls

The role

The Director of Chemistry, Manufacturing and Controls will lead the radiochemistry and CMC organization supporting isotope production programs. This role involves leading process development, technology transfer, and managing a multidisciplinary radiochemistry team.

What you will do

• Lead the CMC and radiochemistry organization for isotope process development and lifecycle management.
• Lead Lu-177 production and Am-241 and Ra-226 processing.
• Establish the technical basis for manufacturing processes.
• Lead development, scale-up, and implementation of radiochemical processes in hot cells and gloveboxes.
• Lead technology transfer and manufacturing readiness.
• Establish and maintain the cGMP technical framework.
• Own the analytical strategy for products, intermediates, impurities, and waste streams.
• Serve as the senior technical authority for process troubleshooting and optimization.
• Support equipment design, commissioning, qualification, and operational readiness.
• Build, mentor, and manage the radiochemistry team.

Required qualifications

• Masters in Radiochemistry, Chemistry, Chemical Engineering, Nuclear Engineering, or a closely related technical discipline.
• 10+ years of progressively responsible experience in radiochemistry, isotope production, radiochemical processing, nuclear chemical operations, pharmaceutical/radiopharmaceutical manufacturing, or a c
• Experience with cGMP manufacturing (US and EU requirements), particularly radiopharmaceuticals, medical isotopes, APIs, radioactive starting materials, or other regulated pharmaceutical manufacturing.
• Experience with CMC development, process characterization, technology transfer, process validation, continued process verification, and manufacturing science and technology (MS&T).
• Direct experience with Lu-177 production, lanthanide separations, target dissolution, radionuclide purification, or medical-isotope manufacturing.
• Demonstrated experience leading technical teams responsible for complex chemical, radiochemical, or manufacturing processes.
• Strong technical background in radiochemical separations, purification, radioactive-material handling, analytical chemistry, and process development.
• Demonstrated experience translating laboratory or development processes into reliable manufacturing operations.
• Experience with process development, scale-up, process optimization, technology transfer, troubleshooting, and technical lifecycle management.
• Experience working in highly regulated environments requiring disciplined procedures, documentation, configuration control, and quality systems.
• Demonstrated ability to lead complex technical investigations and make sound decisions using scientific and engineering data.
• Experience developing technical procedures, specifications, reports, process documentation, and training materials.

Nice to have

• Passionate about unleashing beneficial isotopes and building domestic isotope-production capabilities.
• A strong technical leader who can maintain scientific rigor while moving programs rapidly toward manufacturing.
• Committed to nuclear safety culture, product quality, procedural compliance, and operational excellence.
• Capable of moving comfortably between detailed radiochemical problems and broader program and organizational decisions.
• Able to develop people and build a high-performing technical organization.
• Comfortable making decisions in technically complex environments where complete information may not always be available.
• Effective at translating scientific development into practical, repeatable manufacturing processes.
• Collaborative and able to work across Manufacturing, Facility Operations, Quality, Regulatory, Engineering, Radiation Safety, and Supply Chain.
• Comfortable in a fast-paced, highly iterative startup environment.
• Willing to challenge established approaches and develop novel solutions to difficult isotope-production problems.

Benefits

• Flexible time off
• Equity
• Bonuses
• Competitive pay
• 401(k)
• Health insurance (with employer contribution)
• HSA
• FSA
• Flexible work hours
• Wellness credits

Before you apply

• Only applicants who meet the definition of a U.S. person under applicable laws may be eligible.
• Employment may be contingent upon successful completion of a drug screening.
• Employees may be subject to drug testing at any time.

About the company

Oklo Inc. is developing fast fission power plants to deliver clean, reliable, and affordable energy at scale; establishing a domestic supply chain for critical radioisotopes; and advancing nuclear fuel recycling to convert nuclear waste into clean energy.