Senior Director, Medicinal Chemistry Design

The role

This person will lead drug design teams and serve as a program leader to advance Helicons TM modalities. They will develop medicinal chemistry strategies and collaborate with cross-functional teams to drive development candidates.

What you will do

• Lead drug design teams applying an AI design platform to facilitate rapid SAR decision-making.
• Serve as program leader, setting strategy, coordinating cross-functional teams, and driving delivery of development candidates.
• Develop, implement and communicate an integrated medicinal chemistry strategy.
• Use hypothesis-based drug design, incorporating in silico methods to address key optimization issues.
• Drive progression of lead molecules to pharmacological proof-of-concept studies and development candidate nomination.
• Collaborate closely with data scientists to evolve machine learning models.
• Participate in company portfolio and stage-gate reviews.
• Present to scientific advisory board.
• Collaborate with Lead IP Counsel to formulate intellectual property strategies and draft patent applications.
• Mentor colleagues across functions in medicinal chemistry principles.

Required qualifications

• PhD in chemistry and 12+ years of industrial experience, or Master’s degree and 15+ years of experience
• Demonstrated experience in delivery of drug candidates both as medicinal chemistry lead and program leader
• Experience in optimization of induced proximity modalities, such as protein degraders
• Experience in structure-based data analysis and hypothesis-driven drug design
• Collaborative team member with desire to incorporate computational techniques to increase design quality
• Desire and ability to communicate science – from strategy to hypotheses to tactical plans
• Demonstrated ability to utilize AI tools for day-to-day work
• Able to work on-site and attend in-person meetings

Nice to have

• Experience in ADCs or other drug conjugates
• Advanced or innovative use of AI is a strong plus

Benefits

• Annual target bonus
• Equity
• Comprehensive suite of competitive benefits

About the company

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating medicines for patients with serious diseases by unlocking biologically important targets. The company has pioneered a new class of alpha-helical peptides called Helicons™.