Senior Scientist, Clinical Biomarkers - Oncology

The role

The Senior Scientist, Clinical Biomarkers will execute biomarker strategies for oncology programs from pre-IND through Phase 1/2 clinical trials. This individual-contributor role involves translating preclinical findings into clinical strategies, qualifying assays, and analyzing data to inform clinical decisions.

What you will do

• Capture key biomarkers identified in preclinical studies and assess feasibility for clinical translation
• Develop, qualify, and implement fit-for-purpose clinical biomarker assays and vendors
• Conduct hypothesis-driven analysis, interpretation, and presentation of clinical biomarker data
• Establish and maintain collaborative relationships with Data Science and Biology colleagues
• Partner with Clinical Science, Clinical Operations, and Clinical Pharmacology to embed biomarker strategy into protocols
• Track and interpret emerging biomarker literature and competitive landscape

Required qualifications

• Ph.D. in Cancer Biology, Immunology, or a closely related field
• 5+ years of total experience
• At least 2+ years of industry experience in biomarker research spanning pre-IND through Phase 1/2 clinical programs
• Prior experience in preclinical oncology translational research
• In-depth knowledge of fit-for-purpose assay technologies and their implementation in clinical studies
• Direct experience with established and evolving biomarker assay technologies (e.g., spatial omics, multiplex immunoassays, NGS, IHC, flow cytometry, ctDNA/liquid biopsy)
• Proven track record of delivering impactful clinical translational data in close collaboration
• Demonstrated ability to interpret complex biomarker datasets and translate findings into clinical/scientific recommendations
• Excellent written and verbal communication skills
• Experience presenting to cross-functional and external audiences
• Publication record in peer-reviewed oncology/translational research journals
• Demonstrated ability to utilize AI tools for day-to-day work

Nice to have

• Experience in clinical spatial omics assay design, execution, and downstream bioinformatics analysis
• Advanced or innovative use of AI is a strong plus

Benefits

• Annual target bonus
• Equity
• Comprehensive suite of competitive benefits

About the company

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating medicines for patients with serious diseases by unlocking biologically important targets. The company has pioneered a new class of alpha-helical peptides called Helicons™.