Director, Discovery DMPK

The role

You will provide strategic and scientific leadership for peptide DMPK across multiple discovery programs. You will lead the design and integration of ADME/PK studies and partner with cross-functional teams to advance therapeutics from discovery to candidate nomination.

What you will do

• Provide strategic leadership for peptide DMPK across multiple discovery programs.
• Lead the design, interpretation, and integration of in vitro and in vivo ADME/PK studies.
• Serve as a DMPK subject matter expert to medicinal chemistry, pharmacology, and toxicology.
• Identify and address key DMPK risks and development challenges.
• Provide scientific oversight of external CROs and partners.
• Present DMPK strategies and risk/benefit recommendations to project teams and senior leadership.
• Provide DMPK leadership for regulatory strategy and submissions including IND/NDA.
• Co-lead the development and implementation of AI-enabled DMPK workflows.
• Build and advance DMPK capabilities in bioanalysis and peptide transporter sciences.
• Mentor and provide scientific guidance to junior scientists.

Required qualifications

• PhD (or equivalent) in DMPK, pharmacology, biology, chemistry, pharmaceutical sciences, or a related discipline with 10+ years of relevant industry experience, or MS with 13+ years of relevant experie
• Track record of leading DMPK strategy across multiple discovery and development programs.
• Deep understanding of peptide and small molecule ADME/PK principles.
• Strong understanding of human translation, including PK/PD relationships, human PK and dose projection, transporter/DDI assessment, and exposure-response relationships.
• Proficiency with Phoenix WinNonlin and R for PK analysis, data interpretation, and PK/PD reporting.
• Significant experience selecting and overseeing external CRO partners.
• Expert-level DMPK guidance for regulatory submissions.
• Scientific leadership and influencing skills to drive decisions across cross-functional stakeholders.
• Excellent verbal and written communication skills.
• Ability to utilize AI tools in day-to-day scientific work.
• Able to work on-site and participate regularly in in-person project and leadership meetings.

Nice to have

• Experience with biologics
• Hands-on modeling or regulated bioanalysis experience
• Advanced or innovative application of AI to DMPK analysis, data interpretation, or scientific workflows

Benefits

• Annual target bonus
• Equity
• Comprehensive suite of competitive benefits

About the company

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating medicines for patients with serious diseases by unlocking biologically important targets. The company has pioneered a new class of alpha-helical peptides called Helicons™.