Principal Associate Scientist, Biology

The role

This scientist will support the advancement of pre-clinical oncology programs. They will design and execute cellular and molecular experiments to understand how Helicon candidates engage targets and alter cancer-cell biology.

What you will do

• Design, optimize, execute, and troubleshoot cell-based assays to characterize lead Helicons.
• Develop and apply cellular and molecular assays across 2D and 3D cell models.
• Develop, optimize, and qualify new assay systems and disease-relevant models.
• Investigate biological contexts associated with sensitivity and resistance to lead Helicons.
• Work with Translational Biology, DMPK and in vivo Pharmacology colleagues to select informative models.
• Collaborate with other functions to generate biology data supporting lead optimization and IND-enabling activities.
• Present experimental results and recommendations to project teams and the company.
• Maintain complete, timely and traceable experimental records.

Required qualifications

• B.S. in cell biology, molecular biology, cancer biology or a related field with 8+ years of industry experience in biotechnology or pharmaceuticals, or an M.S. with 6+ years.
• Substantial hands-on experience with mammalian cell biology, cell culture and quantitative cell-based pharmacology or assay development.
• Proficiency in cell and molecular biology techniques such as HTRF, AlphaLISA, CETSA, Western, Co-IP, qPCR, CyQUANT, Flow Cytometry, ELISA/MSD, Imaging, etc.
• Experience using CRISPR/Cas9, RNAi, viral expression/transduction, or related genetic approaches to investigate biological mechanisms.
• Ability to adapt published methods to novel scientific questions and build working relationships with collaborators.
• Strong organizational skills and meticulous attention to detail in experimental documentation.
• Collaborative mindset with a high degree of initiative, curiosity, and enthusiasm.

Nice to have

• Experience studying determinants of drug response or resistance and developing pharmacodynamic or response-biomarker hypotheses
• Experience in oncology drug discovery
• Familiarity with peptides, targeted protein degradation, or other therapeutic modalities beyond conventional small molecules

Benefits

• Annual target bonus
• Equity
• Comprehensive suite of competitive benefits

About the company

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating medicines for patients with serious diseases by unlocking biologically important targets. The company has pioneered a new class of alpha-helical peptides called Helicons.