Director, Medicinal Chemistry Synthesis

The role

You will lead a medicinal chemistry peptide synthesis team to advance Helicons, degraders, and other induced proximity molecules. You will design synthetic routes and partner with various internal teams to achieve hit-to-lead and lead optimization milestones.

What you will do

• Lead a medicinal chemistry peptide synthesis team to generate alpha-helical peptides, E3 ligands, protein degraders and other bifunctional-induced proximity molecules.
• Design and execute efficient synthetic routes from simple building blocks to structurally complex molecules.
• Develop, implement, and communicate integrated synthesis strategies in partnership with other teams.
• Drive data-informed decision-making to accelerate compound synthesis progression.
• Manage and cultivate productive partnerships with external CRO collaborators.
• Partner with internal synthesis and purification teams to streamline workflows.
• Mentor, coach, and develop team members.

Required qualifications

• Ph.D. in Chemistry
• 10+ years of industry experience
• Demonstrated expertise in synthetic route design and execution across a range of molecular complexities
• Strong background in synthetic methodology development, complex problem solving, and modern small-molecule synthesis
• Experience leading projects and managing external CRO partnerships
• Collaborative approach and a desire to incorporate novel synthetic tools to improve efficiency
• Innovative thinking, a growth mindset, and a willingness to challenge conventional approaches
• Passion for drug discovery and advancing novel therapeutic modalities
• Excellent communication, organizational, and collaboration skills
• Ability to independently prioritize and deliver against timelines aligned with company objectives
• Demonstrated ability to utilize AI tools for day-to-day work
• Ability to work on-site and attend in-person meetings

Nice to have

• Experience in solid-phase peptide synthesis is preferred

Benefits

• Annual target bonus
• Equity
• Comprehensive suite of competitive benefits

About the company

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating medicines for patients with serious diseases by unlocking biologically important targets. The company has pioneered a new class of alpha-helical peptides called Helicons™.