Executive Director / Vice President, Biology & Translational Pharmacology

The role

You will lead the scientific strategy and execution of a gene editing therapeutic portfolio. You will oversee translational biology and in vivo pharmacology to advance genetic medicines for severe inborn metabolic diseases.

What you will do

• Build and oversee a liver biology and translational pharmacology organization
• Lead scientific strategy and execution for liver-directed genetic medicine programs
• Provide leadership for cross-functional therapeutic program teams
• Partner with functional leaders to define program resourcing, timelines, and risks
• Guide in vivo pharmacology strategy across rodent and NHP studies
• Design experiments to distinguish mechanism, causality, and therapeutic impact
• Translate portfolio vision into actionable program strategy
• Represent program strategy and data to executive leadership, board members, and partners
• Cultivate a collaborative, execution-oriented culture

Required qualifications

• PhD, MD, DVM, PharmD, or equivalent advanced degree in pharmacology, molecular biology, genetics, physiology, hepatology, bioengineering, medicine, or a related discipline
• PhD in related discipline with significant (12+ years) biopharma R&D experience
• Strong track record in genetic medicines, liver biology, translational pharmacology, and preclinical development
• Deep experience with genetic medicines or advanced therapeutic modalities such as RNAi, antisense oligonucleotides, mRNA/LNP therapeutics, gene therapy, or genome editing
• Deep understanding of liver biology and metabolic disease
• Extensive experience with rare liver diseases, lipid biology, hepatology, fibrosis biology, and/or metabolic liver disease
• Experience designing and interpreting in vivo pharmacology studies including rodent and/or NHP studies
• Demonstrated ability to lead multidisciplinary scientific teams
• Working knowledge of IND-enabling requirements, toxicology interfaces, CMC considerations, bioanalytical assay needs, and regulatory expectations
• Outstanding written and verbal communication skills
• Direct experience or high-level familiarity with gene editing proteins such as nucleases, base editors, prime editors, recombinases, etc
• Team-centered and deeply collaborative

Nice to have

• Experience advancing at least one program into IND-enabling studies or clinical development

Benefits

• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities

Before you apply

• Applicants must have ongoing work authorization in the United States that does not require employer sponsorship
• Sponsorship will not be provided now or at any time in the future for this position
• Legal authorization to work in the United States is required

About the company

Profluent is the frontier AI lab for biology. The company builds foundation models for molecules to transform medicine and agriculture.