Associate Scientist/Engineer II Technology, Development and Operations - Chemistry

The role

The Associate Scientist/Engineer II will support the development, optimization, and tech transfer of a manufacturing process for Prime Editing. This role involves hands-on process development and manufacturing activities including solid-phase chemical synthesis and downstream purification.

What you will do

• Perform routine and non-routine solid-phase chemical synthesis of long guide RNA and downstream purification.
• Work with team members to incorporate technical and analytical findings into process design.
• Conduct hands-on manufacturing of IND-enabling and GLP/GMP RNA guides.
• Author technical reports, standard operating procedures, and draft batch records.
• Organize and present experimental data in written and oral formats.
• Maintain lab instruments such as ÄKTA synthesizers, AKTA purifiers, preparative scale HPLC, and TFF skids.
• Apply AI tools in CMC work to improve processes.
• Support new technology evaluations regarding product quality, productivity, and process robustness.
• Keep meticulous experimental records in an electronic lab notebook.
• Critically evaluate experimental data and communicate findings in team settings.

Required qualifications

• BS or MS in biotechnology, engineering, chemistry, biochemistry, or related life science discipline.
• 3+ years (BS) or 1+ years (MS) of relevant industry experience in biotech/biopharma.
• Experience working in a GMP manufacturing environment, including equipment qualification, investigation, troubleshooting, and operations.
• Working knowledge of statistical software (e.g., JMP) for process analysis and data visualization.
• Strong written and verbal communication skills.
• Ability to manage time effectively and escalate relevant issues.
• Self-motivated and driven with a can-do attitude.
• Capable of continuous learning, open-minded, curious, highly organized, and detail-oriented.
• Able to work both independently and collaboratively in a fast-paced, dynamic, entrepreneurial, and team-based setting.

Nice to have

• Experience in chemistry process development of complex biomolecules
• Experience in oligonucleotide synthesis or downstream purification
• Prior hands-on experience with equipment and unit operations typically used in process development and manufacture of RNA
• Prior experience developing and writing standard operating procedures and draft batch records

Benefits

• Medical
• Dental
• Vision
• Life insurance
• 401(k) match
• Equity programs
• Generous paid time off
• Wellness days
• Company-wide recharge breaks

About the company

Prime Medicine is a biotechnology company leveraging its proprietary Prime Editing platform to develop gene editing therapies. The company focuses on therapeutic programs in hematology, immunology & oncology, liver, and lung.