Executive Director, Supply Chain & External Manufacturing

The role

The Executive Director of Supply Chain and External Manufacturing will own the end-to-end supply chain from raw materials through clinical supply and commercialization. This person will manage external manufacturing partners and lead a lean team while using AI to drive operations.

What you will do

• Define manufacturing and supply chain strategy including network design and partner selection
• Lead the use of AI and digital tools across supply chain and external manufacturing
• Own materials management including forecasting, sourcing, purchasing, and inventory
• Support internal planning and the manufacturing needs of each program
• Deliver labeling, packaging, shipping, and cell therapy logistics
• Build and manage a network of CDMOs, CROs, and critical suppliers
• Ensure supply chain documentation and external site readiness support IND and BLA submissions
• Own TDO budget development for external spend and financial reporting
• Lead, coach, and inspire the supply chain and external manufacturing team

Required qualifications

• Bachelor’s degree in a relevant technical discipline
• 15–20+ years of progressive experience in supply chain, technical operations, external manufacturing, process development, or MSAT within biotech or pharma
• Direct ownership of materials management and clinical supply for clinical-stage programs
• Experience managing CDMOs and CROs, including negotiating MSAs and SOWs
• Experience with cell therapy and/or LNP or nucleic acid programs
• Experience supporting IND/CTA and BLA/MAA submissions
• Financial acumen, including ownership of operating budgets and multi-year cost projections
• Track record of implementing AI or digital tools that improved forecasting, visibility, or decision-making in supply chain or operations
• Strong change management, project management, and communication skills

Nice to have

• Advanced degree (MS, MBA, or PhD)
• Lean, fast-moving biotech experience
• Ultra-rare disease or small patient population experience

Benefits

• Medical
• Dental
• Vision
• Life insurance
• 401(k) match
• Equity programs
• Generous paid time off
• Wellness days
• Company-wide recharge breaks

About the company

Prime Medicine is a clinical-stage biotechnology company creating the next generation of gene editing therapies using its Prime Editing platform. The company is a mission-driven team working in a lean, fast-moving environment.