Research Associate I/II, Protein Chemistry & Bioconjugation (Contract)

The role

This person will support the production, modification, and characterization of antibodies, proteins, and bioconjugates. The role focuses on bench-scale protein chemistry and bioconjugation to enable downstream assay development and candidate selection.

What you will do

• Execute common bioconjugation reactions.
• Prepare and characterize antibody- and protein-conjugated constructs.
• Perform post-conjugation purification techniques including desalting columns and TFF.
• Perform standard protein analytics and concentration measurements.
• Prepare formulation buffers and working reagents.
• Conduct buffer exchange and protein concentration.
• Maintain accurate experimental records and SOPs in an electronic lab notebook (ELN).
• Ensure proper inventory management of reagents, consumables, and protein stocks.
• Present data clearly and provide actionable recommendations to project teams.
• Collaborate cross-functionally with targeting, protein engineering, analytical, and translational teams.

Required qualifications

• B.S. or M.S. in Biochemistry, Bioengineering, Chemistry, or a related field
• BS + 1–4 years of hands-on laboratory experience in a biotech, pharma, or academic research setting
• MS + 0–2 years of hands-on laboratory experience in a biotech, pharma, or academic research setting
• Proficiency in protein concentration measurement (UV-Vis spectroscopy, BCA, Bradford)
• Proficiency in protein characterization techniques (SDS-PAGE, DLS)
• Proficiency in buffer preparation and formulation
• Proficiency in buffer exchange via dialysis
• Hands-on experience with at least one bioconjugation chemistry approach (e.g., NHS ester, maleimide, click chemistry)
• Strong attention to detail, excellent organizational skills, and rigorous documentation habits
• Ability to work independently and collaboratively in a fast-paced research environment

Nice to have

• Experience with antibody-drug conjugates (ADCs)
• Familiarity with TFF systems including µPulse TFF
• Experience with SEC-HPLC or analytical HPLC for purity/conjugation analysis
• Experience with protein purification workflows including IMAC, SEC, and ion exchange chromatography
• Experience with data analysis tools (GraphPad Prism, imageJ)

Benefits

• Certain employee benefits may be available to the contractor through the staffing company after meeting minimum criteria.

About the company

Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a new field of targeted medicines by exploiting naturally occurring commensal viruses. The company was founded in Flagship Pioneering’s venture creation engine.