Principal Scientist I / II, Medicinal Chemistry

The role

A Principal Scientist in Medicinal Chemistry will contribute to drug discovery programs. This role involves supporting medicinal chemistry strategies and managing chemistry CROs to deliver clinical candidates.

What you will do

• Contribute to Schrödinger’s drug discovery programs as a medicinal chemist
• Support and execute medicinal chemistry strategies to deliver high quality clinical candidates
• Manage chemistry CROs to ensure efficient program execution
• Collaborate with computational chemists and modelers on the application of Schrödinger’s computational platform

Required qualifications

• PhD in synthetic organic or medicinal chemistry
• At least four years of drug discovery experience in a pharmaceutical and/or biotech setting
• Proficiency in Structure-Based Drug Design (SBDD)
• Extensive experience in working with external chemistry teams at CROs
• Contemporary knowledge of key Medicinal Chemistry concepts
• Good understanding of biology, pharmacology, drug metabolism and pharmacokinetics
• Experience working in geographically distributed teams

Nice to have

• Experience in leading drug discovery projects (as medicinal chemistry lead or project lead)
• Experience with therapeutic modalities beyond small molecules in particular with peptides and bRo5 chemical space

Benefits

• Competitive salary
• Equity-based compensation
• Healthcare (with dental and vision)
• 401k
• Pre-tax commuter benefits
• Flexible work schedule
• Parental leave program
• Catered meals in the office
• Over a month of paid vacation time

About the company

Schrödinger uses breakthrough computational methods to discover and develop drugs that improve human health. The company has a drug discovery and early clinical development team supported by software developers, engineers, and large-scale computational infrastructure.