Associate Scientist, Pilot Lab, tLNP Drug Product

The role

This person will develop and operationalize lipid nanoparticle formulations at pre-clinical and pilot lab scales. They will work at the interface of manufacturing, formulation science, analytical characterization, and process development.

What you will do

• Design, formulate, and characterize lipid nanoparticle (LNP) systems for nucleic acid delivery
• Develop, optimize and operationalize formulation processes and scale-up approaches
• Troubleshoot formulation and process challenges
• Generate high-quality, reproducible data and maintain documentation in electronic lab notebooks
• Prepare LNP formulations to support internal research and partner programs
• Collaborate cross-functionally with analytical, translational and platform teams
• Present data and insights to internal teams

Required qualifications

• 4+ years (M.Sc.) or 6+ years (B.Sc.) of relevant industry experience in LNP formulation optimizations and drug delivery
• Strong background in nucleic acid therapeutics
• Education in life sciences or engineering (Pharmaceutical Sciences, Biomedical Engineering, Biochemistry, etc)
• Hands-on experience in nanoparticle or LNP formulation and characterization
• Strong understanding of drug delivery systems, particularly for nucleic acid therapeutics
• Experience with nanoparticle characterization techniques (e.g., DLS, zeta potential, fluorescence-based assays such as Ribogreen, chromatography)
• Demonstrated ability to design, execute, and troubleshoot experiments independently
• Strong data analysis, documentation, and communication skills

Nice to have

• Familiarity with formulation process technologies (e.g., microfluidic mixers, pumping systems, TFF)
• Experience supporting in vivo studies or translating formulations from research to preclinical scale

About the company

Sail Biomedicines is seeking a scientist to advance our lipid nanoparticle (LNP) manufacturing platform for nucleic acid therapeutics.