Senior Research Associate, High-Throughput RNA Production

The role

This person will carry out the end-to-end process of high-throughput RNA production from template plasmid cloning to RNA generation and clean up. The role serves to advance programmable circular RNA technology.

What you will do

• Perform high-throughput cloning of plasmid constructs and RNA generation through in vitro transcription (IVT)
• Determine circularization efficiency and impurity levels by running analytic assays
• Coordinate DNA synthesis and scale-up orders with external vendors
• Manage raw material and RNA inventories
• Collaborate with automation engineer to improve process workflow
• Maintain detailed documentation in electronic lab notebooks
• Present findings clearly to platform teams and contribute to scientific discussions and decision-making

Required qualifications

• B.S. in Life Sciences, Chemistry, Engineering, or a related field with 2+ years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
• Ability to manage multiple tasks at once efficiently
• Strong collaborative spirit and communication skills
• Excellent record keeping

Nice to have

• Experience in molecular biology including cloning, RNA production and purification
• Familiarity with high-performance liquid chromatography (HPLC) or other column-based purification/analytic methods
• Experience with automated liquid handling systems (e.g., Hamilton) and high-throughput laboratory workflows
• Experience using data analysis and information management tools, such as Excel, Graphic Prism, SnapGene, Benchling
• Experience in inventory management

About the company

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail was founded by Flagship Pioneering.