Scientist, Platform RNA Sciences

The role

The Scientist, Platform RNA Sciences will work on projects to advance programmable circular RNA technology. This role involves performing hypothesis-driven experiments and high-throughput screens to improve eRNA designs.

What you will do

• Conceive and conduct pooled and array screens to improve eRNA designs
• Design hypothesis-driven experiments to refine eRNA designs
• Evaluate and develop alternative circularization strategies
• Determine circularization efficiency and impurity levels by running analytic assays
• Design controlled experiments, generate high-quality data, and run statistical analysis
• Maintain detailed documentation in electronic lab notebooks
• Author standard operating procedures, study summaries, and technical reports
• Present findings to internal and external stakeholders

Required qualifications

• Ph.D. in Molecular Biology, Biochemistry, or a related field, or M.S. with 6+ years of focused, full-time research experience in RNA technologies
• Strong background in RNA biology
• Skillset in in vitro transcription (IVT), RNA purification, oligo-dT purification, column chromatography, capillary gel electrophoresis, RT-qPCR, RNA-seq, Nanopore sequencing
• Experience using Excel, Graphic Prism, R, JMP, SnapGene, Benchling, Smartsheet, Jira
• Ability to independently design and carry out experiments
• Ability to manage multiple tasks and prioritize
• Collaborative spirit
• Organizational and communication skills
• Excellent record keeping

Nice to have

• Experience in Next Generation Sequencing (NGS) library preparation
• Working knowledge in engineering ribozyme, aptamer or other complex RNA structures

About the company

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines. Sail was founded by Flagship Pioneering.