Research Associate I/Research Associate II, Preclinical Manufacturing

The role

This person will support the production of RNA and lipid nanoparticle (LNP) drug substances and drug products. You will work in the Technical Operations group to develop and deliver preclinical materials for internal and partnered programs.

What you will do

• Support the production of RNA cargo molecules and lipid nanoparticle (LNP) formulations for preclinical studies
• Execute hands-on laboratory work involving eRNA synthesis, purification, and LNP encapsulation
• Contribute to the development, optimization, and scale-up of high-yield, high-quality RNA/LNP processes
• Operate and maintain lab-scale instrumentation, including AKTA (FPLC), TFF systems, PCR, HPLC, capillary electrophoresis, UV-Vis, and light scattering platforms
• Perform analytical characterization and quantification of RNA and other nucleic acids
• Analyze experimental data and document results in electronic lab notebooks (ELN) and technical reports
• Collaborate cross-functionally with research, analytical, and process development teams to support project goals

Required qualifications

• B.S. with 2+ years of industry experience or M.S. in Molecular Biology, Biochemistry, Biochemical Engineering, or a related field
• Hands-on experience in one or more of the following areas: RNA/DNA production and purification, LNP formulation and characterization, Chromatography (e.g., AKTA/FPLC, HPLC), Tangential flow filtration
• Strong understanding of experimental design, data analysis, and technical documentation
• Proficiency in core laboratory techniques, including aseptic technique, buffer preparation, and instrument operation/programming

Nice to have

• Experience with analytical methods such as capillary electrophoresis, UV-Vis, or light scattering
• Detail-oriented with strong organizational and documentation skills
• Curious, proactive, and comfortable working both independently and in collaborative environments
• Effective communicator with the ability to clearly present technical data and insights

About the company

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail was founded by Flagship Pioneering.