Senior Scientist, RNA Process Sciences and Innovation

The role

This Senior Scientist will lead Process Sciences and Innovation across mRNA platforms. The role involves identifying and implementing next-generation technologies to improve mRNA development, manufacturing, and product quality.

What you will do

• Own the technology scouting function for Process Development.
• Design and execute experimental studies for mRNA synthesis and purification.
• Partner with Analytical Development to implement advanced characterization methods and PAT.
• Evaluate emerging instrumentation, automation, digital technologies, and data science approaches.
• Develop strategies to improve process performance, scalability, and product quality.
• Serve as a subject matter expert in mRNA process development.
• Lead scientific investigations into complex process and product challenges.
• Establish mechanistic understanding of critical process parameters and material attributes.
• Maintain awareness of scientific advances through conferences and professional networks.
• Mentor junior scientists and maintain electronic laboratory notebooks and technical reports.

Required qualifications

• B.S. or Advanced Degree in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences, Biotechnology, Biochemistry, Molecular Biology, or a related scientific discipline.
• Significant industry experience developing mRNA, saRNA, circRNA or related nucleic acid therapeutic products.
• Deep understanding of DNA/mRNA synthesis, purification, and characterization.
• Proven track record of identifying, evaluating, and implementing new technologies, methodologies, or workflows.
• Demonstrated ability to think creatively and challenge conventional approaches.
• Strong understanding of process development principles and the relationship between process parameters, material attributes, and product quality.
• Experience collaborating across scientific disciplines.
• Experience with Design of Experiments (DOE), multivariate analysis, mechanistic process understanding, and data-driven process optimization approaches.
• Demonstrated ability to independently lead technical initiatives.
• Strong oral and written communication skills.

Nice to have

• Familiarity with advanced analytical technologies, process analytical technologies (PAT), in-line monitoring, automation, digital process development, and advanced data analysis techniques.
• Passionate about advancing the state of the art in RNA therapeutics and nanoparticle delivery technologies.

Benefits

• Health
• Dental
• Life
• Open PTO
• Onsite lunch catering
• Commuter support
• Work/life flexibility and integration

About the company

Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics. Headquartered in Boston, MA, the company uses its proprietary Signal Stack platform to enable precise control of therapeutic activity.